The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

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Fission pathway: beta-ketoadipate (all branches)

Full Name
beta-ketoadipate (all branches)
Funneling Branch
beta-ketoadipate branch
Synonyms
3-oxoadipate pathway
3-ketoadipate pathway

Pathway Network Visualization 📥 Export BioPAX JSON-LD

Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Cupriavidus necator JMP134 Pérez-Pantoja et al (2008)
Pseudomonas putida KT2440 Poblete-Castro et al (2012)
Candida tropicalis HP15 Krug et al (1985)
Rhodococcus opacus DSM 1069 Kosa et al (2011)
Rhodococcus jostii RHA1 McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 Qi et al (2007)
Acinetobacter baylyi ADP1 Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 COOK et al (1974)
Rhodotorula graminis WP1 Durham et al (1984)
Streptomyces viridosporus T7A Davis et al (2009)
Candida parapsilosis CBS604 Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) Sutherland (1986)
Rhodococcus fascians AY730713 Song (2009)
Achromobacter denitrificans SP1 Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 Davis et al (2009)
Trichosporon cutaneum CBS2466 Anderson et al (1980)
Agrobacterium tumefaciens B6 Parke et al (1986)
Aspergillus nidulans FGSC A4 Martins et al (2015)
Fusarium oxysporum 4287 Michielse et al (2012)
Trametes versicolor Strain 1 Alexieva et al (2010)
Pseudomonas fluorescens AN103 Narbad et al (1998)
Pseudomonas stutzeri A1501 Li et al (2010)
Cupriavidus basilensis B-8 Shi et al (2013)
Acinetobacter radioresistens S13 Mazzoli et al (2007)
Pseudomonas putida PRS2000 Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) Henson et al (2018)
Natrialba sp. C21 Khemili-Talbi et al (2015)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 catechol, protocatechuic acid Bache et al (1981)
Acinetobacter calcoaceticus DSM 586 protocatechuic acid Delneri et al (1995)
Acinetobacter junii 5ga catechol González et al (1993)
Aeromonas sp. L17 protocatechuic acid Deschamps et al (1980)
Azotobacter vinelandii ATCC 12837 catechol Groseclose et al (1981)
Burkholderia cepacia KK01 catechol Kato et al (1998)
Burkholderia cepacia Song isolate 1 catechol, protocatechuic acid Song (2009)
Candida albicans CBS562 catechol Gérecová et al (2015)
Candida dubliniensis CBS7987 catechol Gérecová et al (2015)
Candida maltosa Fialova isolate catechol Fialová et al (2004)
Candida orthopsilosis MCO457 protocatechuic acid Gérecová et al (2015)
Candida tropicalis CBS94 catechol Gérecová et al (2015)
Comamonas testosteroni BR6020 protocatechuic acid Providenti et al (2006)
Cryptococcus terreus PB4 catechol Bergauer et al (2005)
Cupriavidus laharis 1263a catechol Sato et al (2006)
Cupriavidus pinatubonensis 1245 catechol, protocatechuic acid Sato et al (2006)
Desulfobacterium catecholicum NZva20 catechol, protocatechuic acid Szewzyk et al (1987)
Enterobacter aerogenes L7 protocatechuic acid Deschamps et al (1980)
Enterobacter cloacae P241 protocatechuic acid Yoshida et al (2010)
Exophiala jeanselmei CBS 658.76 catechol, protocatechuic acid Middelhoven (1993)
Flavimonas oryzihabitans Song isolate 4 catechol, protocatechuic acid Song (2009)
Klebsiella pneumoniae M5a1 protocatechuic acid Jones et al (1990)
Leucosporidium scottii G43 catechol Middelhoven (1993)
Mastigobasidium intermedium PB8 catechol Bergauer et al (2005)
Microbacterium esteraromaticum Song isolate 5 catechol, protocatechuic acid Song (2009)
Microbotryomycetidae sp. AG15 catechol Bergauer et al (2005)
Oceanimonas doudoroffii JCM21046T protocatechuic acid Numata et al (2015)
Paenibacillus glucanolyticus SLM1 catechol Mathews et al (2014)
Paenibacillus sp. JJ-1b protocatechuic acid Kasai et al (2009)
Pantoea dispersa Song isolate 2 catechol, protocatechuic acid Song (2009)
Papillibacter cinnamivorans CIN1 catechol Defnoun et al (2000)
Pelobacter acidigallici Ma Gal2 (DSM 2377) protocatechuic acid Schink et al (1982)
Phialophora mutabilis 203-E-15-y-l protocatechuic acid Eriksson et al (1984)
Pseudomonas putida Perestelo isolate 3 catechol, protocatechuic acid Perestelo et al (1996)
Pseudomonas sp. HR199 protocatechuic acid Overhage et al (1999)
Pseudomonas sp. MT1 catechol Pelz et al (1999)
Rhodococcus erythropolis 1CP catechol Eulberg et al (1997)
Rhodococcus erythropolis TA421 catechol, protocatechuic acid Chung et al (1994)
Rhodococcus fascians Song isolate 3 catechol, protocatechuic acid Song (2009)
Rhodococcus rhodochrous 116 protocatechuic acid Karlson et al (1993)
Rhodococcus sp. UKMP-5M protocatechuic acid Azman (2015)
Rhodopseudomonas palustris CGA001 protocatechuic acid Harwood et al (1988)
Rhodosporidium lusitaniae PB14 catechol Bergauer et al (2005)
Rhodotorula creatinivora PB7 catechol Bergauer et al (2005)
Rhodotorula rubra IFO 889 protocatechuic acid Huang et al (1993)
Rhodotorula vanillica IGC 4506 catechol Sampaio (1995)
Sinorhizobium meliloti Rm1021 protocatechuic acid MacLean et al (2006)
Sporobolomyces roseus AG13 catechol Bergauer et al (2005)
Thauera aromatica K172 protocatechuic acid Mechichi et al (2002)
Thauera sp. Cin3,4 catechol, protocatechuic acid Mechichi et al (2005)
Treponema primitia ZAS-1 catechol, protocatechuic acid Lucey et al (2013)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Cupriavidus necator JMP134 3-carboxy-cis,cis-muconate cycloisomerase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 3-carboxy-cis,cis-muconate cycloisomerase Krug et al (1985)
Rhodococcus opacus DSM 1069 3-carboxy-cis,cis-muconate cycloisomerase Kosa et al (2011)
Rhodococcus jostii RHA1 3-carboxy-cis,cis-muconate cycloisomerase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 3-carboxy-cis,cis-muconate cycloisomerase Qi et al (2007)
Acinetobacter baylyi ADP1 3-carboxy-cis,cis-muconate cycloisomerase Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 3-carboxy-cis,cis-muconate cycloisomerase COOK et al (1974)
Rhodotorula graminis WP1 3-carboxy-cis,cis-muconate cycloisomerase Durham et al (1984)
Streptomyces viridosporus T7A 3-carboxy-cis,cis-muconate cycloisomerase Davis et al (2009)
Candida parapsilosis CBS604 3-carboxy-cis,cis-muconate cycloisomerase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) 3-carboxy-cis,cis-muconate cycloisomerase Sutherland (1986)
Rhodococcus fascians AY730713 3-carboxy-cis,cis-muconate cycloisomerase Song (2009)
Achromobacter denitrificans SP1 3-carboxy-cis,cis-muconate cycloisomerase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 3-carboxy-cis,cis-muconate cycloisomerase Davis et al (2009)
Trichosporon cutaneum CBS2466 3-carboxy-cis,cis-muconate cycloisomerase Anderson et al (1980)
Agrobacterium tumefaciens B6 3-carboxy-cis,cis-muconate cycloisomerase Parke et al (1986)
Aspergillus nidulans FGSC A4 3-carboxy-cis,cis-muconate cycloisomerase Martins et al (2015)
Fusarium oxysporum 4287 3-carboxy-cis,cis-muconate cycloisomerase Michielse et al (2012)
Trametes versicolor Strain 1 3-carboxy-cis,cis-muconate cycloisomerase Alexieva et al (2010)
Pseudomonas fluorescens AN103 3-carboxy-cis,cis-muconate cycloisomerase Narbad et al (1998)
Pseudomonas stutzeri A1501 3-carboxy-cis,cis-muconate cycloisomerase Li et al (2010)
Cupriavidus basilensis B-8 3-carboxy-cis,cis-muconate cycloisomerase Shi et al (2013)
Acinetobacter radioresistens S13 3-carboxy-cis,cis-muconate cycloisomerase Mazzoli et al (2007)
Pseudomonas putida PRS2000 3-carboxy-cis,cis-muconate cycloisomerase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) 3-carboxy-cis,cis-muconate cycloisomerase Henson et al (2018)
Natrialba sp. C21 3-carboxy-cis,cis-muconate cycloisomerase Khemili-Talbi et al (2015)
Cupriavidus necator JMP134 3-oxoadipate enol-lactonase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 3-oxoadipate enol-lactonase Krug et al (1985)
Rhodococcus opacus DSM 1069 3-oxoadipate enol-lactonase Kosa et al (2011)
Rhodococcus jostii RHA1 3-oxoadipate enol-lactonase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 3-oxoadipate enol-lactonase Qi et al (2007)
Acinetobacter baylyi ADP1 3-oxoadipate enol-lactonase Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 3-oxoadipate enol-lactonase COOK et al (1974)
Rhodotorula graminis WP1 3-oxoadipate enol-lactonase Durham et al (1984)
Streptomyces viridosporus T7A 3-oxoadipate enol-lactonase Davis et al (2009)
Candida parapsilosis CBS604 3-oxoadipate enol-lactonase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) 3-oxoadipate enol-lactonase Sutherland (1986)
Rhodococcus fascians AY730713 3-oxoadipate enol-lactonase Song (2009)
Achromobacter denitrificans SP1 3-oxoadipate enol-lactonase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 3-oxoadipate enol-lactonase Davis et al (2009)
Trichosporon cutaneum CBS2466 3-oxoadipate enol-lactonase Anderson et al (1980)
Agrobacterium tumefaciens B6 3-oxoadipate enol-lactonase Parke et al (1986)
Aspergillus nidulans FGSC A4 3-oxoadipate enol-lactonase Martins et al (2015)
Fusarium oxysporum 4287 3-oxoadipate enol-lactonase Michielse et al (2012)
Trametes versicolor Strain 1 3-oxoadipate enol-lactonase Alexieva et al (2010)
Pseudomonas fluorescens AN103 3-oxoadipate enol-lactonase Narbad et al (1998)
Pseudomonas stutzeri A1501 3-oxoadipate enol-lactonase Li et al (2010)
Cupriavidus basilensis B-8 3-oxoadipate enol-lactonase Shi et al (2013)
Acinetobacter radioresistens S13 3-oxoadipate enol-lactonase Mazzoli et al (2007)
Pseudomonas putida PRS2000 3-oxoadipate enol-lactonase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) 3-oxoadipate enol-lactonase Henson et al (2018)
Natrialba sp. C21 3-oxoadipate enol-lactonase Khemili-Talbi et al (2015)
Cupriavidus necator JMP134 4-carboxymuconolactone decarboxylase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 4-carboxymuconolactone decarboxylase Krug et al (1985)
Rhodococcus opacus DSM 1069 4-carboxymuconolactone decarboxylase Kosa et al (2011)
Rhodococcus jostii RHA1 4-carboxymuconolactone decarboxylase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 4-carboxymuconolactone decarboxylase Qi et al (2007)
Acinetobacter baylyi ADP1 4-carboxymuconolactone decarboxylase Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 4-carboxymuconolactone decarboxylase COOK et al (1974)
Rhodotorula graminis WP1 4-carboxymuconolactone decarboxylase Durham et al (1984)
Streptomyces viridosporus T7A 4-carboxymuconolactone decarboxylase Davis et al (2009)
Candida parapsilosis CBS604 4-carboxymuconolactone decarboxylase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) 4-carboxymuconolactone decarboxylase Sutherland (1986)
Rhodococcus fascians AY730713 4-carboxymuconolactone decarboxylase Song (2009)
Achromobacter denitrificans SP1 4-carboxymuconolactone decarboxylase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 4-carboxymuconolactone decarboxylase Davis et al (2009)
Trichosporon cutaneum CBS2466 4-carboxymuconolactone decarboxylase Anderson et al (1980)
Agrobacterium tumefaciens B6 4-carboxymuconolactone decarboxylase Parke et al (1986)
Aspergillus nidulans FGSC A4 4-carboxymuconolactone decarboxylase Martins et al (2015)
Fusarium oxysporum 4287 4-carboxymuconolactone decarboxylase Michielse et al (2012)
Trametes versicolor Strain 1 4-carboxymuconolactone decarboxylase Alexieva et al (2010)
Pseudomonas fluorescens AN103 4-carboxymuconolactone decarboxylase Narbad et al (1998)
Pseudomonas stutzeri A1501 4-carboxymuconolactone decarboxylase Li et al (2010)
Cupriavidus basilensis B-8 4-carboxymuconolactone decarboxylase Shi et al (2013)
Acinetobacter radioresistens S13 4-carboxymuconolactone decarboxylase Mazzoli et al (2007)
Pseudomonas putida PRS2000 4-carboxymuconolactone decarboxylase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) 4-carboxymuconolactone decarboxylase Henson et al (2018)
Natrialba sp. C21 4-carboxymuconolactone decarboxylase Khemili-Talbi et al (2015)
Cupriavidus necator JMP134 Protocatechuate 3,4-dioxygenase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 Protocatechuate 3,4-dioxygenase Krug et al (1985)
Rhodococcus opacus DSM 1069 Protocatechuate 3,4-dioxygenase Kosa et al (2011)
Rhodococcus jostii RHA1 Protocatechuate 3,4-dioxygenase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 Protocatechuate 3,4-dioxygenase Qi et al (2007)
Acinetobacter baylyi ADP1 Protocatechuate 3,4-dioxygenase Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 Protocatechuate 3,4-dioxygenase COOK et al (1974)
Rhodotorula graminis WP1 Protocatechuate 3,4-dioxygenase Durham et al (1984)
Streptomyces viridosporus T7A Protocatechuate 3,4-dioxygenase Davis et al (2009)
Candida parapsilosis CBS604 Protocatechuate 3,4-dioxygenase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) Protocatechuate 3,4-dioxygenase Sutherland (1986)
Rhodococcus fascians AY730713 Protocatechuate 3,4-dioxygenase Song (2009)
Achromobacter denitrificans SP1 Protocatechuate 3,4-dioxygenase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 Protocatechuate 3,4-dioxygenase Davis et al (2009)
Trichosporon cutaneum CBS2466 Protocatechuate 3,4-dioxygenase Anderson et al (1980)
Agrobacterium tumefaciens B6 Protocatechuate 3,4-dioxygenase Parke et al (1986)
Aspergillus nidulans FGSC A4 Protocatechuate 3,4-dioxygenase Martins et al (2015)
Fusarium oxysporum 4287 Protocatechuate 3,4-dioxygenase Michielse et al (2012)
Trametes versicolor Strain 1 Protocatechuate 3,4-dioxygenase Alexieva et al (2010)
Pseudomonas fluorescens AN103 Protocatechuate 3,4-dioxygenase Narbad et al (1998)
Pseudomonas stutzeri A1501 Protocatechuate 3,4-dioxygenase Li et al (2010)
Cupriavidus basilensis B-8 Protocatechuate 3,4-dioxygenase Shi et al (2013)
Acinetobacter radioresistens S13 Protocatechuate 3,4-dioxygenase Mazzoli et al (2007)
Pseudomonas putida PRS2000 Protocatechuate 3,4-dioxygenase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) Protocatechuate 3,4-dioxygenase Henson et al (2018)
Natrialba sp. C21 Protocatechuate 3,4-dioxygenase Khemili-Talbi et al (2015)
Cupriavidus necator JMP134 catechol 1,2-dioxygenase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 catechol 1,2-dioxygenase Krug et al (1985)
Rhodococcus opacus DSM 1069 catechol 1,2-dioxygenase Kosa et al (2011)
Rhodococcus jostii RHA1 catechol 1,2-dioxygenase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 catechol 1,2-dioxygenase Qi et al (2007)
Rhodotorula mucilaginosa CBS17 catechol 1,2-dioxygenase COOK et al (1974)
Rhodotorula graminis WP1 catechol 1,2-dioxygenase Durham et al (1984)
Streptomyces viridosporus T7A catechol 1,2-dioxygenase Davis et al (2009)
Candida parapsilosis CBS604 catechol 1,2-dioxygenase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) catechol 1,2-dioxygenase Sutherland (1986)
Rhodococcus fascians AY730713 catechol 1,2-dioxygenase Song (2009)
Achromobacter denitrificans SP1 catechol 1,2-dioxygenase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 catechol 1,2-dioxygenase Davis et al (2009)
Trichosporon cutaneum CBS2466 catechol 1,2-dioxygenase Anderson et al (1980)
Agrobacterium tumefaciens B6 catechol 1,2-dioxygenase Parke et al (1986)
Aspergillus nidulans FGSC A4 catechol 1,2-dioxygenase Martins et al (2015)
Fusarium oxysporum 4287 catechol 1,2-dioxygenase Michielse et al (2012)
Trametes versicolor Strain 1 catechol 1,2-dioxygenase Alexieva et al (2010)
Pseudomonas fluorescens AN103 catechol 1,2-dioxygenase Narbad et al (1998)
Pseudomonas stutzeri A1501 catechol 1,2-dioxygenase Li et al (2010)
Cupriavidus basilensis B-8 catechol 1,2-dioxygenase Shi et al (2013)
Pseudomonas putida PRS2000 catechol 1,2-dioxygenase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) catechol 1,2-dioxygenase Henson et al (2018)
Natrialba sp. C21 catechol 1,2-dioxygenase Khemili-Talbi et al (2015)
Cupriavidus necator JMP134 muconate cycloisomerase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 muconate cycloisomerase Krug et al (1985)
Rhodococcus opacus DSM 1069 muconate cycloisomerase Kosa et al (2011)
Rhodococcus jostii RHA1 muconate cycloisomerase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 muconate cycloisomerase Qi et al (2007)
Acinetobacter baylyi ADP1 muconate cycloisomerase Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 muconate cycloisomerase COOK et al (1974)
Rhodotorula graminis WP1 muconate cycloisomerase Durham et al (1984)
Streptomyces viridosporus T7A muconate cycloisomerase Davis et al (2009)
Candida parapsilosis CBS604 muconate cycloisomerase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) muconate cycloisomerase Sutherland (1986)
Rhodococcus fascians AY730713 muconate cycloisomerase Song (2009)
Achromobacter denitrificans SP1 muconate cycloisomerase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 muconate cycloisomerase Davis et al (2009)
Trichosporon cutaneum CBS2466 muconate cycloisomerase Anderson et al (1980)
Agrobacterium tumefaciens B6 muconate cycloisomerase Parke et al (1986)
Aspergillus nidulans FGSC A4 muconate cycloisomerase Martins et al (2015)
Fusarium oxysporum 4287 muconate cycloisomerase Michielse et al (2012)
Trametes versicolor Strain 1 muconate cycloisomerase Alexieva et al (2010)
Pseudomonas fluorescens AN103 muconate cycloisomerase Narbad et al (1998)
Pseudomonas stutzeri A1501 muconate cycloisomerase Li et al (2010)
Cupriavidus basilensis B-8 muconate cycloisomerase Shi et al (2013)
Acinetobacter radioresistens S13 muconate cycloisomerase Mazzoli et al (2007)
Pseudomonas putida PRS2000 muconate cycloisomerase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) muconate cycloisomerase Henson et al (2018)
Natrialba sp. C21 muconate cycloisomerase Khemili-Talbi et al (2015)
Cupriavidus necator JMP134 muconolactone isomerase Pérez-Pantoja et al (2008)
Candida tropicalis HP15 muconolactone isomerase Krug et al (1985)
Rhodococcus opacus DSM 1069 muconolactone isomerase Kosa et al (2011)
Rhodococcus jostii RHA1 muconolactone isomerase McLeod et al (2006)
Corynebacterium glutamicum ATCC13032 muconolactone isomerase Qi et al (2007)
Acinetobacter baylyi ADP1 muconolactone isomerase Bleichrodt et al (2010)
Rhodotorula mucilaginosa CBS17 muconolactone isomerase COOK et al (1974)
Rhodotorula graminis WP1 muconolactone isomerase Durham et al (1984)
Streptomyces viridosporus T7A muconolactone isomerase Davis et al (2009)
Candida parapsilosis CBS604 muconolactone isomerase Holesova et al (2011)
Amycolatopsis sp. 75iv2 (ATCC 39116) muconolactone isomerase Sutherland (1986)
Rhodococcus fascians AY730713 muconolactone isomerase Song (2009)
Achromobacter denitrificans SP1 muconolactone isomerase Benjamin et al (2016)
Streptomyces coelicolor A3(2) M600 muconolactone isomerase Davis et al (2009)
Trichosporon cutaneum CBS2466 muconolactone isomerase Anderson et al (1980)
Agrobacterium tumefaciens B6 muconolactone isomerase Parke et al (1986)
Aspergillus nidulans FGSC A4 muconolactone isomerase Martins et al (2015)
Fusarium oxysporum 4287 muconolactone isomerase Michielse et al (2012)
Trametes versicolor Strain 1 muconolactone isomerase Alexieva et al (2010)
Pseudomonas fluorescens AN103 muconolactone isomerase Narbad et al (1998)
Pseudomonas stutzeri A1501 muconolactone isomerase Li et al (2010)
Cupriavidus basilensis B-8 muconolactone isomerase Shi et al (2013)
Acinetobacter radioresistens S13 muconolactone isomerase Mazzoli et al (2007)
Pseudomonas putida PRS2000 muconolactone isomerase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) muconolactone isomerase Henson et al (2018)
Natrialba sp. C21 muconolactone isomerase Khemili-Talbi et al (2015)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
4 beta-ketoadipate-enol-lactone → beta-ketoadipate - R00004
5 beta-ketoadipate → beta-oxoadipyl-CoA - R00005
6 beta-oxoadipyl-CoA → acetyl-CoA + succinyl-CoA - R00006
(catechol branch) 1 catechol → cis,cis-muconic acid catechol 1,2-dioxygenase R00001
(catechol branch) 2 cis,cis-muconic acid → muconolactone muconate cycloisomerase R00002
(catechol branch) 3 muconolactone → beta-ketoadipate-enol-lactone muconolactone isomerase R00003
(protocatechuate branch) 1 protocatechuic acid → 3-carboxy-cis,cis-muconate Protocatechuate 3,4-dioxygenase R00016
(protocatechuate branch) 2 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate 3-carboxy-cis,cis-muconate cycloisomerase R00017
(protocatechuate branch) 3 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone 4-carboxymuconolactone decarboxylase R00018
(protocatechuate branch) 4 3-oxoadipate enol lactone → beta-ketoadipate 3-oxoadipate enol-lactonase R00019

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
catechol C6H6O2 C1=CC=C(C(=C1)O)O 289 substrate
cis,cis-muconic acid C6H6O4 C(=CC(=O)O)C=CC(=O)O 5280518 product, substrate
muconolactone (intermediate) C6H6O4 C1=CC(=O)OC1CC(=O)O 542 product, substrate
beta-ketoadipate-enol-lactone (intermediate) C6H6O4 C1C=C(OC1=O)CC(=O)O 104 product, substrate
protocatechuic acid C7H6O4 C1=CC(=C(C=C1C(=O)O)O)O 72 substrate
3-carboxy-cis,cis-muconate (intermediate) C7H3O63- C(=CC(=O)[O-])C(=CC(=O)[O-])C(=O)[O-] 9543176 product, substrate
2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate (intermediate) - - - product, substrate
3-oxoadipate enol lactone (intermediate) C6H6O4 C1C=C(OC1=O)CC(=O)O 104 product, substrate
beta-ketoadipate (intermediate) C6H8O5 C(CC(=O)O)C(=O)CC(=O)O 93 product, substrate
beta-oxoadipyl-CoA (intermediate) C27H42N7O20P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(=O)O)O 9543153 product, substrate
acetyl-CoA (intermediate) C23H38N7O17P3S CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O 444493 product
succinyl-CoA (intermediate) C25H40N7O19P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O)O 92133 product

Connected Pathways

Incoming Connections (Pathways connecting to this one:)

Source Pathway Connecting Compound
Funneling pathway: vanillin I protocatechuic acid
Funneling pathway: vanillin II protocatechuic acid
Funneling pathway: benzoic acid catechol
Funneling pathway: caffeic acid protocatechuic acid
Funneling pathway: m-cresol protocatechuic acid
Funneling pathway: guaiacol catechol

Genes

Gene Enzyme
Pp_catA catechol 1,2-dioxygenase
Pp_catB muconate cycloisomerase
Pp_catC muconolactone isomerase
Pp_pcaG Protocatechuate 3,4-dioxygenase
Pp_pcaH Protocatechuate 3,4-dioxygenase
Pp_pcaB 3-carboxy-cis,cis-muconate cycloisomerase
Pp_pcaC 4-carboxymuconolactone decarboxylase
Pp_pcaD 3-oxoadipate enol-lactonase

Other Databases

Database Comment
MetaCyc Metabolic pathway database

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