The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

brinkdp/eLignin 0 0

Funneling pathway: caffeic acid

Full Name
caffeic acid
Funneling Branch
caffeic acid branch

Pathway Network Visualization 📥 Export BioPAX JSON-LD

Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Acinetobacter baylyi ADP1 Ishiyama et al (2004)
Corynebacterium glutamicum ATCC13032 Shen et al (2012)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 caffeic acid Tschech et al (1984)
Brettanomyces anomalus NCYC 615 caffeic acid Edlin et al (1995)
Cupriavidus laharis 1263a caffeic acid Sato et al (2006)
Cupriavidus necator JMP134 caffeic acid Pérez-Pantoja et al (2008)
Cupriavidus pinatubonensis 1245 caffeic acid Sato et al (2006)
Enterobacter aerogenes L7 caffeic acid Deschamps et al (1980)
Enterobacter sp. DG-6 caffeic acid Grbić-Galić (1985)
Leucosporidium scottii G43 caffeic acid Sampaio (1995)
Oceanimonas doudoroffii JCM21046T caffeic acid Numata et al (2015)
Pseudomonas putida KT2440 caffeic acid Jiménez et al (2002)
Rhodopseudomonas palustris CGA001 caffeic acid Harwood et al (1988)
Rhodopseudomonas palustris CGA009 caffeic acid Salmon et al (2013)
Rhodotorula glutinis Jain isolate caffeic acid GUPTA et al (1986)
Rhodotorula mucilaginosa CBS17 caffeic acid Sampaio (1999)
Thauera sp. Cin3,4 caffeic acid Mechichi et al (2005)
Treponema primitia ZAS-1 caffeic acid Lucey et al (2013)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Corynebacterium glutamicum ATCC13032 caffeate coenzyme A ligase Shen et al (2012)
Corynebacterium glutamicum ATCC13032 enoyl-CoA hydratase/lyase Shen et al (2012)
Corynebacterium glutamicum ATCC13032 hydroxybenzaldehyde dehydrogenase Shen et al (2012)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 caffeic acid → caffeoyl-CoA caffeate coenzyme A ligase R00050
2 caffeoyl-CoA → 3,4-dihydroxybenzaldehyde + acetyl-CoA enoyl-CoA hydratase/lyase R00051
3 3,4-dihydroxybenzaldehyde → protocatechuic acid hydroxybenzaldehyde dehydrogenase R00052

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
caffeic acid C9H8O4 C1=CC(=C(C=C1C=CC(=O)O)O)O 689043 substrate
caffeoyl-CoA (intermediate) C30H42N7O19P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C=CC4=CC(=C(C=C4)O)O)O 11966126 product, substrate
3,4-dihydroxybenzaldehyde (intermediate) C7H6O3 C1=CC(=C(C=C1C=O)O)O 8768 product, substrate
acetyl-CoA (intermediate) C23H38N7O17P3S CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O 444493 product
protocatechuic acid C7H6O4 C1=CC(=C(C=C1C(=O)O)O)O 72 product

Connected Pathways

Outgoing Connections (This pathway connects to:)

Connected Pathway Connecting Compound
Fission pathway: protocatechuate 2,3-cleavage protocatechuic acid
Fission pathway: beta-ketoadipate: Protocatechuate branch protocatechuic acid
Fission pathway: beta-ketoadipate (all branches) protocatechuic acid
Fission pathway: protocatechuate 4,5-cleavage protocatechuic acid

Genes

Gene Enzyme
Ab_hcaC caffeate coenzyme A ligase
Ab_hcaA enoyl-CoA hydratase/lyase
Ab_hcaB hydroxybenzaldehyde dehydrogenase

Other Databases

No external database links are available for this pathway.

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