Fission pathway: beta-ketoadipate pathway (all branches)
type: Pathway
id: P00001
name: betaketo
name: 3-oxoadipate pathway
name: 3-ketoadipate pathway
funneling branch: beta-ketoadipate branch
pathway component: catechol → cis,cis-muconic acid
pathway component: cis,cis-muconic acid → muconolactone
pathway component: muconolactone → beta-ketoadipate-enol-lactone
pathway component: protocatechuic acid → 3-carboxy-cis,cis-muconate
pathway component: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
pathway component: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
pathway component: 3-oxoadipate enol lactone → beta-ketoadipate
pathway component: beta-ketoadipate-enol-lactone → beta-ketoadipate
pathway component: beta-ketoadipate → beta-oxoadipyl-CoA
pathway component: beta-oxoadipyl-CoA → acetyl-CoA
pathway order: BiochemicalPathwayStep
  step conversion: catechol → cis,cis-muconic acid
  reac id: R00001
  step order: (catechol branch) 1
  next step: cis,cis-muconic acid → muconolactone
pathway order: BiochemicalPathwayStep
  step conversion: cis,cis-muconic acid → muconolactone
  reac id: R00002
  step order: (catechol branch) 2
  next step: muconolactone → beta-ketoadipate-enol-lactone
pathway order: BiochemicalPathwayStep
  step conversion: muconolactone → beta-ketoadipate-enol-lactone
  reac id: R00003
  step order: (catechol branch) 3
  next step: protocatechuic acid → 3-carboxy-cis,cis-muconate
pathway order: BiochemicalPathwayStep
  step conversion: protocatechuic acid → 3-carboxy-cis,cis-muconate
  reac id: R00016
  step order: (protocatechuate branch) 1
  next step: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
pathway order: BiochemicalPathwayStep
  step conversion: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
  reac id: R00017
  step order: (protocatechuate branch) 2
  next step: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
pathway order: BiochemicalPathwayStep
  step conversion: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
  reac id: R00018
  step order: (protocatechuate branch) 3
  next step: 3-oxoadipate enol lactone → beta-ketoadipate
pathway order: BiochemicalPathwayStep
  step conversion: 3-oxoadipate enol lactone → beta-ketoadipate
  reac id: R00019
  step order: (protocatechuate branch) 4
  next step: beta-ketoadipate → beta-oxoadipyl-CoA
pathway order: BiochemicalPathwayStep
  step conversion: beta-ketoadipate-enol-lactone → beta-ketoadipate
  reac id: R00004
  step order: 4
  next step: beta-ketoadipate → beta-oxoadipyl-CoA
pathway order: BiochemicalPathwayStep
  step conversion: beta-ketoadipate → beta-oxoadipyl-CoA
  reac id: R00005
  step order: 5
  next step: beta-oxoadipyl-CoA → acetyl-CoA
pathway order: BiochemicalPathwayStep
  step conversion: beta-oxoadipyl-CoA → acetyl-CoA
  reac id: R00006
  step order: 6
connections: vanillin I
  type: PathwayConnection
  direction: upstream
  id: P00006
  pathway type: Funneling
  connecting substrate id: S00002
connections: vanillin II
  type: PathwayConnection
  direction: upstream
  id: P00007
  pathway type: Funneling
  connecting substrate id: S00002
connections: benzoic acid
  type: PathwayConnection
  direction: upstream
  id: P00003
  pathway type: Funneling
  connecting substrate id: S00001
connections: caffeic acid
  type: PathwayConnection
  direction: upstream
  id: P00018
  pathway type: Funneling
  connecting substrate id: S00002
connections: m-cresol
  type: PathwayConnection
  direction: upstream
  id: P00021
  pathway type: Funneling
  connecting substrate id: S00002
connections: guaiacol
  type: PathwayConnection
  direction: upstream
  id: P00025
  pathway type: Funneling
  connecting substrate id: S00001
created: 2026-02-28T10:42:00.321169+00:00
elignin note: This file is JSON-LD based on BioPAX Level 3 naming conventions. It is NOT a standards-compliant BioPAX OWL/RDF document. eLignin-specific extensions (elignin_id, connections, genes, …) are mapped to the http://www.elignindatabase.com/ontology# namespace. To convert to canonical BioPAX RDF/XML use pybiopax or a compatible RDF serialiser.

catechol → cis,cis-muconic acid
type: BiochemicalReaction
id: R00001
left: catechol
right: cis,cis-muconic acid
catalysis: Catalysis
  controller: catechol 1,2-dioxygenase
  controlled: catechol → cis,cis-muconic acid

catechol
type: SmallMolecule
id: S00001
chemical formula: C6H6O2
molecular weight: 110.11
xref: UnificationXref
  db: PubChem Compound
  id: 289
xref: UnificationXref
  db: ChEBI
  id: 18135
xref: UnificationXref
  db: KEGG Compound
  id: C00090
xref: UnificationXref
  db: CAS
  id: 120-80-9

cis,cis-muconic acid
type: SmallMolecule
id: S00137
chemical formula: C6H6O4
molecular weight: 142.11
xref: UnificationXref
  db: PubChem Compound
  id: 5280518
xref: UnificationXref
  db: ChEBI
  id: 16508
xref: UnificationXref
  db: KEGG Compound
  id: C02480
xref: UnificationXref
  db: CAS
  id: 505-70-4
xref: UnificationXref
  db: PubChem Compound
  id: 5280518
xref: UnificationXref
  db: ChEBI
  id: 16508
xref: UnificationXref
  db: KEGG Compound
  id: C02480
xref: UnificationXref
  db: CAS
  id: 505-70-4

catechol 1,2-dioxygenase
type: Protein
id: E00001
EC number: 1.13.11.1

cis,cis-muconic acid → muconolactone
type: BiochemicalReaction
id: R00002
left: cis,cis-muconic acid
right: muconolactone
catalysis: Catalysis
  controller: muconate cycloisomerase
  controlled: cis,cis-muconic acid → muconolactone

muconate cycloisomerase
type: Protein
id: E00002
EC number: 5.5.1.1

muconolactone → beta-ketoadipate-enol-lactone
type: BiochemicalReaction
id: R00003
left: muconolactone
right: beta-ketoadipate-enol-lactone
catalysis: Catalysis
  controller: muconolactone isomerase
  controlled: muconolactone → beta-ketoadipate-enol-lactone

muconolactone isomerase
type: Protein
id: E00003
EC number: 5.3.3.4

protocatechuic acid → 3-carboxy-cis,cis-muconate
type: BiochemicalReaction
id: R00016
left: protocatechuic acid
right: 3-carboxy-cis,cis-muconate
catalysis: Catalysis
  controller: Protocatechuate 3,4-dioxygenase
  controlled: protocatechuic acid → 3-carboxy-cis,cis-muconate

protocatechuic acid
type: SmallMolecule
id: S00002
chemical formula: C7H6O4
molecular weight: 153.11
xref: UnificationXref
  db: PubChem Compound
  id: 72
xref: UnificationXref
  db: ChEBI
  id: 36062
xref: UnificationXref
  db: KEGG Compound
  id: C00230
xref: UnificationXref
  db: CAS
  id: 99-50-3

Protocatechuate 3,4-dioxygenase
type: Protein
id: E00011
EC number: 1.13.11.3

3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
type: BiochemicalReaction
id: R00017
left: 3-carboxy-cis,cis-muconate
right: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
catalysis: Catalysis
  controller: 3-carboxy-cis,cis-muconate cycloisomerase
  controlled: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate

3-carboxy-cis,cis-muconate cycloisomerase
type: Protein
id: E00012
EC number: 5.5.1.2

2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
type: BiochemicalReaction
id: R00018
left: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
right: 3-oxoadipate enol lactone
catalysis: Catalysis
  controller: 4-carboxymuconolactone decarboxylase
  controlled: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone

4-carboxymuconolactone decarboxylase
type: Protein
id: E00013
EC number: 4.1.1.44

3-oxoadipate enol lactone → beta-ketoadipate
type: BiochemicalReaction
id: R00019
left: 3-oxoadipate enol lactone
right: beta-ketoadipate
catalysis: Catalysis
  controller: 3-oxoadipate enol-lactonase
  controlled: 3-oxoadipate enol lactone → beta-ketoadipate

3-oxoadipate enol-lactonase
type: Protein
id: E00014
EC number: 3.1.1.24

beta-ketoadipate-enol-lactone → beta-ketoadipate
type: BiochemicalReaction
id: R00004
left: beta-ketoadipate-enol-lactone
right: beta-ketoadipate

beta-ketoadipate → beta-oxoadipyl-CoA
type: BiochemicalReaction
id: R00005
left: beta-ketoadipate
right: beta-oxoadipyl-CoA

beta-oxoadipyl-CoA → acetyl-CoA
type: BiochemicalReaction
id: R00006
left: beta-oxoadipyl-CoA
right: acetyl-CoA
right: succinyl-CoA