The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

brinkdp/eLignin 0 0

Funneling pathway: guaiacol

Full Name
guaiacol
Funneling Branch
coniferyl branch

Pathway Network Visualization 📥 Export BioPAX JSON-LD

Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Rhodococcus opacus PD630 (DSMZ 44193) Henson et al (2018)
Rhodotorula rubra IFO 889 Huang et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) Sutherland et al (1983)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium dehalogenans MC vanillic acid Kaufmann et al (1998)
Acetobacterium woodii NZva16 vanillic acid Bache et al (1981)
Acinetobacter baylyi ADP1 vanillic acid Salvachúa et al (2015), Fischer et al (2008)
Acinetobacter calcoaceticus DSM 586 vanillic acid Delneri et al (1995)
Acinetobacter junii 5ga guaiacol González et al (1993)
Azotobacter vinelandii NBRC13581 vanillic acid Hirose et al (2013)
Bradyrhizobium japonicum USDA110 vanillic acid Sudtachat et al (2009)
Burkholderia cepacia KK01 guaiacol, vanillic acid Kato et al (1998)
Burkholderia cepacia Song isolate 1 vanillic acid -
Ceriporiopsis subvermispora FP-105752 guaiacol Daina et al (2002)
Clostridium methoxybenzovorans SR3 vanillic acid Mechichi et al (2005)
Clostridium thermoaceticum ATCC 39073 vanillic acid Daniel et al (1988)
Comamonas sp. B-9 (CGMCC No. 4251) guaiacol, vanillic acid Chen et al (2012)
Comamonas testosteroni BR6020 vanillic acid Providenti et al (2006)
Comamonas testosteroni CNB-1 vanillic acid Ni et al (2012)
Cupriavidus laharis 1263a vanillic acid Sato et al (2006)
Desulfobacterium catecholicum NZva20 guaiacol Szewzyk et al (1987)
Enterobacter sp. DG-6 guaiacol Grbić-Galić (1985)
Exophiala jeanselmei CBS 658.76 vanillic acid Middelhoven (1993)
Flavobacterium lutescens NBRC3084 vanillic acid Hirose et al (2013)
Fusarium oxysporum 4287 vanillic acid Michielse et al (2012)
Klebsiella sp. LLC-3 vanillic acid Hirose et al (2013)
Leucosporidium scottii G43 vanillic acid Middelhoven (1993)
Marinobacterium georgiense KW-40 vanillic acid GONZaLEZ et al (1997)
Mesorhizobium sp. PT04 guaiacol, vanillic acid Tian et al (2016)
Microbacterium phyllosphaerae A1.1 vanillic acid Taylor et al (2012)
Microbulbifer hydrolyticus IRE-31 vanillic acid GONZaLEZ et al (1997)
Micrococcus luteus E1.1 vanillic acid Taylor et al (2012)
Moraxella sp. GU2 guaiacol Dardas et al (1985), Sterjiades et al (1982)
Oceanimonas doudoroffii JCM21046T vanillic acid Numata et al (2015)
Ochrobactrum pseudogrignonense A4.3 vanillic acid Taylor et al (2012)
Ochrobactrum rhizosphaerae C4.1 vanillic acid Taylor et al (2012)
Ochrobactrum sp. LLC-2 vanillic acid Hirose et al (2013)
Paenibacillus glucanolyticus SLM1 guaiacol Mathews et al (2014)
Pandoraea norimbergensis LD001 vanillic acid Bandounas et al (2011)
Pantoea dispersa Song isolate 2 vanillic acid Song (2009)
Pseudomonas chlororaphis subsp. aureofaciens PT02 guaiacol, vanillic acid Tian et al (2016)
Pseudomonas fluorescens AN103 vanillic acid Paulsen et al (2005)
Pseudomonas fluorescens DSM 50090 vanillic acid Ravi et al (2018)
Pseudomonas mira V2 vanillic acid Jurková et al (1993)
Pseudomonas putida F1 vanillic acid Hirose et al (2013)
Pseudomonas putida KT2440 vanillic acid Salvachúa et al (2015), Ravi et al (2017)
Pseudomonas putida ORC guaiacol Chapman et al (1976)
Pseudomonas putida Perestelo isolate 3 vanillic acid Perestelo et al (1996)
Pseudomonas sp. HR199 vanillic acid Overhage et al (1999)
Pseudomonas sp. Isolate 9.1 vanillic acid Ravi et al (2018)
Pseudomonas sp. KF704 vanillic acid Hirose et al (2013)
Pseudomonas sp. LLC-1 vanillic acid Hirose et al (2013)
Rhizobium sp. YS-1r vanillic acid Jackson et al (2017)
Rhodococcus erythropolis A5.1 vanillic acid Taylor et al (2012)
Rhodococcus fascians AY730713 vanillic acid Song (2009)
Rhodococcus fascians Song isolate 3 vanillic acid Song (2009)
Rhodococcus jostii RHA1 vanillic acid Salvachúa et al (2015)
Rhodococcus opacus DSM 1069 guaiacol, vanillic acid Kosa et al (2011), Ravi et al (2018)
Rhodococcus rhodochrous 116 guaiacol Karlson et al (1993)
Rhodococcus sp. UKMP-5M vanillic acid Azman (2015)
Rhodopseudomonas palustris CGA001 vanillic acid Harwood et al (1988)
Rhodosporidiobolus colostri DBVPG 10655 vanillic acid Margesin et al (2022)
Rhodosporidium toruloides IFO0880 vanillic acid Yaegashi et al (2017)
Rhodotorula sp. R2 vanillic acid Hainal et al (2012)
Rhodotorula mucilaginosa CBS17 vanillic acid Sampaio (1999)
Serratia liquefaciens sp. PT01 guaiacol, vanillic acid Tian et al (2016)
Serratia marcescens C5 vanillic acid Rhoads et al (1995)
Serratia sp. JHT01 guaiacol, vanillic acid Tian et al (2016)
Sphingobacterium sp. T2 vanillic acid Taylor et al (2012)
Sphingobium sp. SYK-6 vanillic acid Katayama et al (1988)
Stenotrophomonas sp. PT03 guaiacol, vanillic acid Tian et al (2016)
Streptomyces sp. D7 vanillic acid Chow et al (1999)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Rhodococcus opacus PD630 (DSMZ 44193) P450 aryl-O-demethylase Henson et al (2018)
Rhodotorula rubra IFO 889 P450 aryl-O-demethylase Huang et al (1993)
Rhodococcus opacus PD630 (DSMZ 44193) non-oxidative vanillate decarboxylase Henson et al (2018)
Rhodotorula rubra IFO 889 non-oxidative vanillate decarboxylase Huang et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) non-oxidative vanillate decarboxylase Sutherland et al (1983)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 vanillic acid → guaiacol non-oxidative vanillate decarboxylase R00074
2 guaiacol + guaiacol → catechol + catechol P450 aryl-O-demethylase R00073

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
vanillic acid C8H8O4 COC1=C(C=CC(=C1)C(=O)O)O 8468 substrate
guaiacol C7H8O2 COC1=CC=CC=C1O 460 product, substrate
catechol C6H6O2 C1=CC=C(C(=C1)O)O 289 product

Connected Pathways

Outgoing Connections (This pathway connects to:)

Connected Pathway Connecting Compound
Fission pathway: beta-ketoadipate (all branches) catechol
Fission pathway: beta-ketoadipate: Catechol branch catechol
Fission pathway: catechol meta-cleavage catechol

Genes

Gene Enzyme
Str_vdcBCD non-oxidative vanillate decarboxylase
Am_GcoAB P450 aryl-O-demethylase

Other Databases

No external database links are available for this pathway.

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