The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

brinkdp/eLignin 0 0

Funneling pathway: p-coumaric acid

Full Name
p-coumaric acid
Funneling Branch
p-coumaric branch

Pathway Network Visualization 📥 Export BioPAX JSON-LD

Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Pseudomonas putida KT2440 Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 Shen et al (2012)
Rhodococcus opacus PD630 (DSMZ 44193) Henson et al (2018)
Amycolatopsis sp. 75iv2 (ATCC 39116) Sutherland et al (1983)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 4-hydroxybenzoic acid Bache et al (1981)
Acinetobacter baumannii KMB1 4-hydroxybenzoic acid Kuhnigk et al (1997)
Acinetobacter baylyi ADP1 4-hydroxybenzoic acid, p-coumaric acid Salvachúa et al (2015), Fischer et al (2008)
Acinetobacter calcoaceticus DSM 586 4-hydroxybenzoic acid, p-coumaric acid Delneri et al (1995)
Aeromonas sp. L17 4-hydroxybenzoic acid Deschamps et al (1980)
Agrobacterium tumefaciens B6 4-hydroxybenzoic acid Parke (1997)
Alcaligenes faecalis KD10 4-hydroxybenzoic acid Kuhnigk et al (1997)
Azoarcus anaerobius LuFRes1 4-hydroxybenzoic acid Gorny et al (1992)
Bacillus cereus KD4 4-hydroxybenzoic acid Kuhnigk et al (1997)
Bacillus licheniformis KB1 4-hydroxybenzoic acid Kuhnigk et al (1997)
Bacillus sphaericus KD7 4-hydroxybenzoic acid Kuhnigk et al (1997)
Bacillus subtilis KD8 4-hydroxybenzoic acid Kuhnigk et al (1997)
Brettanomyces anomalus NCYC 615 p-coumaric acid Edlin et al (1995)
Burkholderia cepacia KF12 4-hydroxybenzoic acid Kuhnigk et al (1997)
Burkholderia cepacia KK01 p-coumaric acid Kato et al (1998)
Burkholderia cepacia Song isolate 1 4-hydroxybenzoic acid Song (2009)
Candida orthopsilosis MCO457 4-hydroxybenzoic acid Gérecová et al (2015)
Candida parapsilosis CBS604 4-hydroxybenzoic acid Middelhoven et al (1992), Gérecová et al (2015)
Comamonas acidovorans KNB3 4-hydroxybenzoic acid Kuhnigk et al (1997)
Comamonas sp. B-9 (CGMCC No. 4251) p-coumaric acid Chen et al (2012)
Comamonas testosteroni BR6020 4-hydroxybenzoic acid Providenti et al (2001)
Comamonas testosteroni CNB-1 4-hydroxybenzoic acid Ni et al (2012)
Cupriavidus necator JMP134 4-hydroxybenzoic acid, p-coumaric acid Salvachúa et al (2015), Pérez-Pantoja et al (2008)
Cupriavidus pinatubonensis 1245 4-hydroxybenzoic acid Sato et al (2006)
Desulfobacterium catecholicum NZva20 4-hydroxybenzoic acid Szewzyk et al (1987)
Desulfobacterium phenolicum Ph01 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid Bak et al (1986)
Enterobacter aerogenes L7 4-hydroxybenzoic acid Deschamps et al (1980)
Exophiala jeanselmei CBS 658.76 4-hydroxybenzoic acid, p-coumaric acid Middelhoven (1993)
Flavimonas oryzihabitans Song isolate 4 4-hydroxybenzoic acid Song (2009)
Fusarium oxysporum 4287 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid, p-coumaric acid Michielse et al (2012)
Haloarcula sp. D1 4-hydroxybenzoic acid Fairley et al (2002)
Haloferax sp. C-24 4-hydroxybenzoic acid Erdoğmuş et al (2013)
Halorubrum ezzemoulense C-46 4-hydroxybenzoic acid Erdoğmuş et al (2013)
Klebsiella pneumoniae M5a1 4-hydroxybenzoic acid Jones et al (1990)
Leucosporidium scottii G43 4-hydroxybenzoic acid Middelhoven (1993)
Marinobacterium georgiense KW-40 4-hydroxybenzoic acid, p-coumaric acid GONZaLEZ et al (1997)
Microbacterium esteraromaticum Song isolate 5 4-hydroxybenzoic acid Song (2009)
Oceanimonas doudoroffii JCM21046T 4-hydroxybenzoic acid, p-coumaric acid Numata et al (2015)
Paenibacillus sp. JJ-1b 4-hydroxybenzoic acid Crawford et al (1979)
Pandoraea norimbergensis LD001 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid Bandounas et al (2011)
Pantoea dispersa Song isolate 2 4-hydroxybenzoic acid Song (2009)
Paraburkholderia aromaticivorans AR20-38 4-hydroxybenzoic acid, p-coumaric acid Margesin et al (2021)
Pseudomonas aeruginosa KMD3 4-hydroxybenzoic acid Kuhnigk et al (1997)
Pseudomonas citronellolis KMA4 4-hydroxybenzoic acid Kuhnigk et al (1997)
Pseudomonas fluorescens AN103 4-hydroxybenzoic acid Paulsen et al (2005)
Pseudomonas fluorescens DSM 50090 4-hydroxybenzoic acid Ravi et al (2018)
Pseudomonas putida PRS2000 4-hydroxybenzoic acid Ornston et al (1976)
Pseudomonas putida Perestelo isolate 3 4-hydroxybenzoic acid, p-coumaric acid Perestelo et al (1996)
Pseudomonas sp. Isolate 9.1 4-hydroxybenzoic acid, p-coumaric acid Ravi et al (2018)
Rhodococcus erythropolis TA421 4-hydroxybenzoic acid Chung et al (1994)
Rhodococcus fascians AY730713 4-hydroxybenzoic acid Song (2009)
Rhodococcus fascians Song isolate 3 4-hydroxybenzoic acid Song (2009)
Rhodococcus jostii RHA1 4-hydroxybenzoic acid, p-coumaric acid Salvachúa et al (2015)
Rhodococcus opacus DSM 1069 4-hydroxybenzoic acid Kosa et al (2011)
Rhodococcus rhodochrous 116 4-hydroxybenzoic acid Karlson et al (1993)
Rhodopseudomonas palustris CGA001 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid, p-coumaric acid Harwood et al (1988)
Rhodopseudomonas palustris CGA009 p-coumaric acid Salmon et al (2013)
Rhodosporidiobolus colostri DBVPG 10655 4-hydroxybenzoic acid, p-coumaric acid Margesin et al (2022)
Rhodosporidium toruloides IFO0880 4-hydroxybenzoic acid, p-coumaric acid Yaegashi et al (2017)
Rhodotorula mucilaginosa CBS17 4-hydroxybenzoic acid, p-coumaric acid Sampaio (1999)
Serratia marcescens C5 4-hydroxybenzoic acid Rhoads et al (1995)
Sphingobium sp. SYK-6 4-hydroxybenzoic acid Katayama et al (1988)
Sphingomonas aromaticivorans F199 4-hydroxybenzoic acid Cecil et al (2018)
Streptomyces coelicolor A3(2) M600 4-hydroxybenzoic acid Davis et al (2009)
Streptomyces sp. ZC2 4-hydroxybenzoic acid Kuhnigk et al (1997)
Sulfuritalea hydrogenivorans sk43H 4-hydroxybenzoic acid Sperfeld et al (2018)
Thauera aromatica K172 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid Tschech et al (1987)
Thauera sp. Cin3,4 4-hydroxybenzoic acid, p-coumaric acid Mechichi et al (2005)
Trichosporon cutaneum CBS2466 4-hydroxybenzoic acid Middelhoven (1993)
Trichosporon oleaginosus ATCC 20509 4-hydroxybenzoic acid Yaguchi et al (2017)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Pseudomonas putida KT2440 4-hydroxybenzaldehyde dehydrogenase Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 4-hydroxybenzaldehyde dehydrogenase Shen et al (2012)
Rhodococcus opacus PD630 (DSMZ 44193) 4-hydroxybenzaldehyde dehydrogenase Henson et al (2018)
Amycolatopsis sp. 75iv2 (ATCC 39116) 4-hydroxybenzaldehyde dehydrogenase Sutherland et al (1983)
Corynebacterium glutamicum ATCC13032 4-hydroxybenzoate 3-monooxygenase Shen et al (2012)
Rhodococcus opacus PD630 (DSMZ 44193) 4-hydroxybenzoate 3-monooxygenase Henson et al (2018)
Amycolatopsis sp. 75iv2 (ATCC 39116) 4-hydroxybenzoate 3-monooxygenase Sutherland et al (1983)
Pseudomonas putida KT2440 caffeate coenzyme A ligase Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 caffeate coenzyme A ligase Shen et al (2012)
Rhodococcus opacus PD630 (DSMZ 44193) caffeate coenzyme A ligase Henson et al (2018)
Amycolatopsis sp. 75iv2 (ATCC 39116) caffeate coenzyme A ligase Sutherland et al (1983)
Pseudomonas putida KT2440 enoyl-CoA hydratase/lyase Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 enoyl-CoA hydratase/lyase Shen et al (2012)
Rhodococcus opacus PD630 (DSMZ 44193) enoyl-CoA hydratase/lyase Henson et al (2018)
Amycolatopsis sp. 75iv2 (ATCC 39116) enoyl-CoA hydratase/lyase Sutherland et al (1983)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 p-coumaric acid → p-coumaroyl-CoA - R00061
2 p-comaroyl-CoA → 4-hydroxybenzaldehyde + acetyl-CoA enoyl-CoA hydratase/lyase R00062
3 4-hydroxybenzaldehyde → 4-hydroxybenzoic acid 4-hydroxybenzaldehyde dehydrogenase R00038
4 4-hydroxybenzoic acid → protocatechuic acid - R00037

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
p-coumaric acid C9H8O3 C1=CC(=CC=C1C=CC(=O)O)O 637542 substrate
p-coumaroyl-CoA (intermediate) C30H42N7O18P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C=CC4=CC=C(C=C4)O)O 6440013 product
p-comaroyl-CoA (intermediate) C30H42N7O18P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C=CC4=CC=C(C=C4)O)O 6440013 substrate
4-hydroxybenzaldehyde C7H6O2 C1=CC(=CC=C1C=O)O 126 product, substrate
acetyl-CoA (intermediate) C23H38N7O17P3S CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O 444493 product
4-hydroxybenzoic acid C7H6O3 C1=CC(=CC=C1C(=O)O)O 135 product, substrate
protocatechuic acid C7H6O4 C1=CC(=C(C=C1C(=O)O)O)O 72 product

Connected Pathways

Outgoing Connections (This pathway connects to:)

Connected Pathway Connecting Compound
Fission pathway: beta-ketoadipate: Protocatechuate branch protocatechuic acid
Fission pathway: protocatechuate 4,5-cleavage protocatechuic acid
Fission pathway: protocatechuate 2,3-cleavage protocatechuic acid

Genes

Gene Enzyme
Ab_hcaA enoyl-CoA hydratase/lyase
Pp_pchA 4-hydroxybenzaldehyde dehydrogenase

Other Databases

No external database links are available for this pathway.

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