The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

brinkdp/eLignin 0 0

4-hydroxybenzoic acid

Compound Overview

Name 4-hydroxybenzoic acid
IUPAC Name 4-Hydroxybenzoic acid
Formula C7H6O3
SMILES C1=CC(=CC=C1C(=O)O)O
Carbon Number 7
Molecular Weight 138.12
Polymer Type monomer
Synonyms p-Hydroxybenzoic acid
para-Hydroxybenzoic acid
PHBA
4-Hydroxybenzoate
p-Salicylic acid
p-Carboxyphenol
4-Hydroxybenzoic acid

Chemical Structure

Chemical structure of 4-hydroxybenzoic acid

Structure from PubChem

External Databases

CAS 99-96-7
PubChem 135
KEGG C00156
ChEBI 30763
Empirical Data

Organisms that can utilize this substrate (69) Empirical

📥 Download as TSV
Organism ▲ ▼ Strain ▲ ▼ Reference ▲ ▼ Comment ▲ ▼
Rhodococcus rhodochrous 116 Karlson et al (1993), Karlson et al (1993) -
Cupriavidus pinatubonensis 1245 Sato et al (2006) -
Fusarium oxysporum 4287 Michielse et al (2012) -
Amycolatopsis sp. 75iv2 (ATCC 39116) Pometto III et al (1981), Sutherland et al (1983) -
Streptomyces coelicolor A3(2) M600 Davis et al (2009) -
Acinetobacter baylyi ADP1 Salvachúa et al (2015), Fischer et al (2008) -
Pseudomonas fluorescens AN103 Paulsen et al (2005) -
Paraburkholderia aromaticivorans AR20-38 Margesin et al (2021) -
Trichosporon oleaginosus ATCC 20509 Yaguchi et al (2017) -
Rhodococcus fascians AY730713 Song (2009) -
Agrobacterium tumefaciens B6 Parke (1997) -
Comamonas testosteroni BR6020 Providenti et al (2001) -
Haloferax sp. C-24 Erdoğmuş et al (2013) -
Halorubrum ezzemoulense C-46 Erdoğmuş et al (2013) -
Serratia marcescens C5 Rhoads et al (1995) -
Exophiala jeanselmei CBS 658.76 Middelhoven (1993) -
Rhodotorula mucilaginosa CBS17 Sampaio (1999) -
Trichosporon cutaneum CBS2466 Middelhoven (1993) -
Candida parapsilosis CBS604 Middelhoven et al (1992), Gérecová et al (2015) -
Rhodopseudomonas palustris CGA001 Harwood et al (1988) -
Comamonas testosteroni CNB-1 Ni et al (2012) -
Thauera sp. Cin3,4 Mechichi et al (2005) -
Haloarcula sp. D1 Fairley et al (2002) -
Rhodosporidiobolus colostri DBVPG 10655 Margesin et al (2022) -
Rhodococcus opacus DSM 1069 Kosa et al (2011) -
Pseudomonas fluorescens DSM 50090 Ravi et al (2018) -
Acinetobacter calcoaceticus DSM 586 Delneri et al (1995) -
Sphingomonas aromaticivorans F199 Cecil et al (2018) -
Leucosporidium scottii G43 Middelhoven (1993) -
Rhodosporidium toruloides IFO0880 Yaegashi et al (2017) -
Pseudomonas sp. Isolate 9.1 Ravi et al (2018) -
Oceanimonas doudoroffii JCM21046T Numata et al (2015) -
Paenibacillus sp. JJ-1b Crawford et al (1979) -
Cupriavidus necator JMP134 Salvachúa et al (2015), Pérez-Pantoja et al (2008) -
Thauera aromatica K172 Tschech et al (1987), Tschech et al (1987) (anaerobically)
(anaerobically)
Bacillus licheniformis KB1 Kuhnigk et al (1997) -
Alcaligenes faecalis KD10 Kuhnigk et al (1997) -
Bacillus cereus KD4 Kuhnigk et al (1997) -
Bacillus sphaericus KD7 Kuhnigk et al (1997) -
Bacillus subtilis KD8 Kuhnigk et al (1997) -
Burkholderia cepacia KF12 Kuhnigk et al (1997) -
Pseudomonas citronellolis KMA4 Kuhnigk et al (1997) -
Acinetobacter baumannii KMB1 Kuhnigk et al (1997) -
Pseudomonas aeruginosa KMD3 Kuhnigk et al (1997) -
Comamonas acidovorans KNB3 Kuhnigk et al (1997) -
Pseudomonas putida KT2440 Salvachúa et al (2015), Ravi et al (2017) -
Marinobacterium georgiense KW-40 GONZaLEZ et al (1997) -
Aeromonas sp. L17 Deschamps et al (1980) -
Enterobacter aerogenes L7 Deschamps et al (1980) -
Pandoraea norimbergensis LD001 Bandounas et al (2011) -
Azoarcus anaerobius LuFRes1 Gorny et al (1992) (anaerobically)
Klebsiella pneumoniae M5a1 Jones et al (1990) -
Candida orthopsilosis MCO457 Gérecová et al (2015) -
Acetobacterium woodii NZva16 Bache et al (1981) (anaerobically)
Desulfobacterium catecholicum NZva20 Szewzyk et al (1987) (anaerobically)
Rhodococcus opacus PD630 (DSMZ 44193) Henson et al (2018) -
Pseudomonas putida PRS2000 Ornston et al (1976) -
Pseudomonas putida Perestelo isolate 3 Perestelo et al (1996) -
Desulfobacterium phenolicum Ph01 Bak et al (1986), Bak et al (1986) (anaerobically)
(anaerobically)
Rhodococcus jostii RHA1 Salvachúa et al (2015) -
Sphingobium sp. SYK-6 Katayama et al (1988) -
Burkholderia cepacia Song isolate 1 Song (2009) -
Pantoea dispersa Song isolate 2 Song (2009) -
Rhodococcus fascians Song isolate 3 Song (2009) -
Flavimonas oryzihabitans Song isolate 4 Song (2009) -
Microbacterium esteraromaticum Song isolate 5 Song (2009) -
Rhodococcus erythropolis TA421 Chung et al (1994) -
Streptomyces sp. ZC2 Kuhnigk et al (1997) -
Sulfuritalea hydrogenivorans sk43H Sperfeld et al (2018) (anaerobically)

Pathways Empirical

Pathway Name Full Name
p-coumaric acid p-coumaric acid
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
Predicted sections are hidden. Show them

Organisms predicted to process 4-hydroxybenzoic acid through a pathway Predicted

For each pathway where 4-hydroxybenzoic acid enters as a reactant, organisms recorded as being able to utilise it but not yet confirmed for that pathway are listed as predicted. Not experimentally verified. What does this mean?

📥 Download as TSV
Organism Strain Inferred via pathway Reference confirming 4-hydroxybenzoic acid utilization
Acetobacterium woodii NZva16 p-coumaric acid Bache et al (1981)
Acinetobacter baumannii KMB1 p-coumaric acid Kuhnigk et al (1997)
Acinetobacter baylyi ADP1 p-coumaric acid Salvachúa et al (2015), Fischer et al (2008)
Acinetobacter calcoaceticus DSM 586 p-coumaric acid Delneri et al (1995)
Aeromonas sp. L17 p-coumaric acid Deschamps et al (1980)
Agrobacterium tumefaciens B6 p-coumaric acid Parke (1997)
Alcaligenes faecalis KD10 p-coumaric acid Kuhnigk et al (1997)
Azoarcus anaerobius LuFRes1 p-coumaric acid Gorny et al (1992)
Bacillus cereus KD4 p-coumaric acid Kuhnigk et al (1997)
Bacillus licheniformis KB1 p-coumaric acid Kuhnigk et al (1997)
Bacillus sphaericus KD7 p-coumaric acid Kuhnigk et al (1997)
Bacillus subtilis KD8 p-coumaric acid Kuhnigk et al (1997)
Burkholderia cepacia KF12 p-coumaric acid Kuhnigk et al (1997)
Burkholderia cepacia Song isolate 1 p-coumaric acid Song (2009)
Candida orthopsilosis MCO457 p-coumaric acid Gérecová et al (2015)
Candida parapsilosis CBS604 p-coumaric acid Middelhoven et al (1992), Gérecová et al (2015)
Comamonas acidovorans KNB3 p-coumaric acid Kuhnigk et al (1997)
Comamonas testosteroni BR6020 p-coumaric acid Providenti et al (2001)
Comamonas testosteroni CNB-1 p-coumaric acid Ni et al (2012)
Cupriavidus necator JMP134 p-coumaric acid Salvachúa et al (2015), Pérez-Pantoja et al (2008)
Cupriavidus pinatubonensis 1245 p-coumaric acid Sato et al (2006)
Desulfobacterium catecholicum NZva20 p-coumaric acid Szewzyk et al (1987)
Desulfobacterium phenolicum Ph01 p-coumaric acid Bak et al (1986)
Enterobacter aerogenes L7 p-coumaric acid Deschamps et al (1980)
Exophiala jeanselmei CBS 658.76 p-coumaric acid Middelhoven (1993)
Flavimonas oryzihabitans Song isolate 4 p-coumaric acid Song (2009)
Fusarium oxysporum 4287 p-coumaric acid Michielse et al (2012)
Haloarcula sp. D1 p-coumaric acid Fairley et al (2002)
Haloferax sp. C-24 p-coumaric acid Erdoğmuş et al (2013)
Halorubrum ezzemoulense C-46 p-coumaric acid Erdoğmuş et al (2013)
Klebsiella pneumoniae M5a1 p-coumaric acid Jones et al (1990)
Leucosporidium scottii G43 p-coumaric acid Middelhoven (1993)
Marinobacterium georgiense KW-40 p-coumaric acid GONZaLEZ et al (1997)
Microbacterium esteraromaticum Song isolate 5 p-coumaric acid Song (2009)
Oceanimonas doudoroffii JCM21046T p-coumaric acid Numata et al (2015)
Paenibacillus sp. JJ-1b p-coumaric acid Crawford et al (1979)
Pandoraea norimbergensis LD001 p-coumaric acid Bandounas et al (2011)
Pantoea dispersa Song isolate 2 p-coumaric acid Song (2009)
Paraburkholderia aromaticivorans AR20-38 p-coumaric acid Margesin et al (2021)
Pseudomonas aeruginosa KMD3 p-coumaric acid Kuhnigk et al (1997)
Pseudomonas citronellolis KMA4 p-coumaric acid Kuhnigk et al (1997)
Pseudomonas fluorescens AN103 p-coumaric acid Paulsen et al (2005)
Pseudomonas fluorescens DSM 50090 p-coumaric acid Ravi et al (2018)
Pseudomonas putida PRS2000 p-coumaric acid Ornston et al (1976)
Pseudomonas putida Perestelo isolate 3 p-coumaric acid Perestelo et al (1996)
Pseudomonas sp. Isolate 9.1 p-coumaric acid Ravi et al (2018)
Rhodococcus erythropolis TA421 p-coumaric acid Chung et al (1994)
Rhodococcus fascians AY730713 p-coumaric acid Song (2009)
Rhodococcus fascians Song isolate 3 p-coumaric acid Song (2009)
Rhodococcus jostii RHA1 p-coumaric acid Salvachúa et al (2015)
Rhodococcus opacus DSM 1069 p-coumaric acid Kosa et al (2011)
Rhodococcus rhodochrous 116 p-coumaric acid Karlson et al (1993)
Rhodopseudomonas palustris CGA001 p-coumaric acid Harwood et al (1988)
Rhodosporidiobolus colostri DBVPG 10655 p-coumaric acid Margesin et al (2022)
Rhodosporidium toruloides IFO0880 p-coumaric acid Yaegashi et al (2017)
Rhodotorula mucilaginosa CBS17 p-coumaric acid Sampaio (1999)
Serratia marcescens C5 p-coumaric acid Rhoads et al (1995)
Sphingobium sp. SYK-6 p-coumaric acid Katayama et al (1988)
Sphingomonas aromaticivorans F199 p-coumaric acid Cecil et al (2018)
Streptomyces coelicolor A3(2) M600 p-coumaric acid Davis et al (2009)
Streptomyces sp. ZC2 p-coumaric acid Kuhnigk et al (1997)
Sulfuritalea hydrogenivorans sk43H p-coumaric acid Sperfeld et al (2018)
Thauera aromatica K172 p-coumaric acid Tschech et al (1987)
Thauera sp. Cin3,4 p-coumaric acid Mechichi et al (2005)
Trichosporon cutaneum CBS2466 p-coumaric acid Middelhoven (1993)
Trichosporon oleaginosus ATCC 20509 p-coumaric acid Yaguchi et al (2017)

Reactions involving 4-hydroxybenzoic acid

Reaction Role in Reaction
4-hydroxybenzoic acid + NADPH + oxygen + H+ → protocatechuic acid + NADP+ + H2O substrate
4-hydroxybenzaldehyde + NADP+ + H2O → 4-hydroxybenzoic acid + NADPH + 2 H+ product

Transporters

Transporter Reference
Cg_pcaKp Chaudhry et al (2007)
Pp_pcaKp Nichols et al (1997)
Ab_vanKp D’Argenio et al (1999)
Ab_pcaKp D’Argenio et al (1999)

← Back to substrate list