The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

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Fission pathway: beta-ketoadipate: Catechol branch

Full Name
beta-ketoadipate: Catechol branch
Funneling Branch
beta-ketoadipate branch
Synonyms
3-oxoadipate pathway: catechol branch
3-ketoadipate pathway: catechol branch
catechol <i>ortho</i>-cleavage pathway

Pathway Network Visualization 📥 Export BioPAX JSON-LD

Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Rhodococcus erythropolis 1CP Eulberg et al (1997)
Burkholderia cepacia ATCC 29351 Hamzah et al (1994)
Pseudomonas putida KT2440 Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 Shen et al (2012)
Pseudomonas putida PRS2000 Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) Henson et al (2018)
Natrialba sp. C21 Khemili-Talbi et al (2015)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 catechol Bache et al (1981)
Acinetobacter baylyi ADP1 catechol, cis,cis-muconic acid Collier et al (1997)
Acinetobacter junii 5ga catechol González et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) catechol, cis,cis-muconic acid Davis et al (2012), Pometto III et al (1981), Antai et al (1983), Barton et al (2018)
Azotobacter vinelandii ATCC 12837 catechol Groseclose et al (1981)
Burkholderia cepacia KK01 catechol Kato et al (1998)
Burkholderia cepacia Song isolate 1 catechol Song (2009)
Candida albicans CBS562 catechol Gérecová et al (2015)
Candida dubliniensis CBS7987 catechol Gérecová et al (2015)
Candida maltosa Fialova isolate catechol Fialová et al (2004)
Candida tropicalis CBS94 catechol Gérecová et al (2015)
Candida tropicalis HP15 catechol Krug et al (1985)
Cryptococcus terreus PB4 catechol Bergauer et al (2005)
Cupriavidus laharis 1263a catechol Sato et al (2006)
Cupriavidus necator JMP134 catechol Pérez-Pantoja et al (2008)
Cupriavidus pinatubonensis 1245 catechol Sato et al (2006)
Desulfobacterium catecholicum NZva20 catechol Szewzyk et al (1987)
Exophiala jeanselmei CBS 658.76 catechol Middelhoven (1993)
Flavimonas oryzihabitans Song isolate 4 catechol Song (2009)
Fusarium oxysporum 4287 catechol Michielse et al (2012)
Leucosporidium scottii G43 catechol Middelhoven (1993)
Mastigobasidium intermedium PB8 catechol Bergauer et al (2005)
Microbacterium esteraromaticum Song isolate 5 catechol Song (2009)
Microbotryomycetidae sp. AG15 catechol Bergauer et al (2005)
Paenibacillus glucanolyticus SLM1 catechol Mathews et al (2014)
Pantoea dispersa Song isolate 2 catechol Song (2009)
Papillibacter cinnamivorans CIN1 catechol Defnoun et al (2000)
Pseudomonas fluorescens AN103 catechol Paulsen et al (2005)
Pseudomonas putida Perestelo isolate 3 catechol Perestelo et al (1996)
Pseudomonas sp. MT1 catechol Pelz et al (1999)
Rhodococcus erythropolis TA421 catechol Chung et al (1994)
Rhodococcus fascians AY730713 catechol Song (2009)
Rhodococcus fascians Song isolate 3 catechol Song (2009)
Rhodococcus jostii RHA1 catechol Kasai et al (2015)
Rhodosporidium lusitaniae PB14 catechol Bergauer et al (2005)
Rhodotorula creatinivora PB7 catechol Bergauer et al (2005)
Rhodotorula graminis WP1 catechol Durham et al (1984)
Rhodotorula vanillica IGC 4506 catechol Sampaio (1995)
Sporobolomyces roseus AG13 catechol Bergauer et al (2005)
Thauera sp. Cin3,4 catechol Mechichi et al (2005)
Treponema primitia ZAS-1 catechol Lucey et al (2013)
Trichosporon cutaneum CBS2466 catechol Middelhoven (1993)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Rhodococcus erythropolis 1CP catechol 1,2-dioxygenase Eulberg et al (1997)
Burkholderia cepacia ATCC 29351 catechol 1,2-dioxygenase Hamzah et al (1994)
Corynebacterium glutamicum ATCC13032 catechol 1,2-dioxygenase Shen et al (2012)
Pseudomonas putida PRS2000 catechol 1,2-dioxygenase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) catechol 1,2-dioxygenase Henson et al (2018)
Natrialba sp. C21 catechol 1,2-dioxygenase Khemili-Talbi et al (2015)
Rhodococcus erythropolis 1CP muconate cycloisomerase Eulberg et al (1997)
Burkholderia cepacia ATCC 29351 muconate cycloisomerase Hamzah et al (1994)
Corynebacterium glutamicum ATCC13032 muconate cycloisomerase Shen et al (2012)
Pseudomonas putida PRS2000 muconate cycloisomerase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) muconate cycloisomerase Henson et al (2018)
Natrialba sp. C21 muconate cycloisomerase Khemili-Talbi et al (2015)
Rhodococcus erythropolis 1CP muconolactone isomerase Eulberg et al (1997)
Burkholderia cepacia ATCC 29351 muconolactone isomerase Hamzah et al (1994)
Corynebacterium glutamicum ATCC13032 muconolactone isomerase Shen et al (2012)
Pseudomonas putida PRS2000 muconolactone isomerase Ornston et al (1976)
Rhodococcus opacus PD630 (DSMZ 44193) muconolactone isomerase Henson et al (2018)
Natrialba sp. C21 muconolactone isomerase Khemili-Talbi et al (2015)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 catechol → cis,cis-muconic acid catechol 1,2-dioxygenase R00001
2 cis,cis-muconic acid → muconolactone muconate cycloisomerase R00002
3 muconolactone → beta-ketoadipate-enol-lactone muconolactone isomerase R00003

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
catechol C6H6O2 C1=CC=C(C(=C1)O)O 289 substrate
cis,cis-muconic acid C6H6O4 C(=CC(=O)O)C=CC(=O)O 5280518 product, substrate
muconolactone (intermediate) C6H6O4 C1=CC(=O)OC1CC(=O)O 542 product, substrate
beta-ketoadipate-enol-lactone (intermediate) C6H6O4 C1C=C(OC1=O)CC(=O)O 104 product

Connected Pathways

Outgoing Connections (This pathway connects to:)

Connected Pathway Connecting Compound
Fission pathway: beta-ketoadipate: lower branch -

Incoming Connections (Pathways connecting to this one:)

Source Pathway Connecting Compound
Funneling pathway: benzoic acid catechol
Funneling pathway: phenol catechol
Funneling pathway: salicylic acid I catechol
Funneling pathway: guaiacol catechol

Genes

Gene Enzyme
Pp_catA catechol 1,2-dioxygenase
Pp_catB muconate cycloisomerase
Pp_catC muconolactone isomerase

Other Databases

Database Comment
MetaCyc Metabolic pathway database

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