Funneling pathway: guaiacol
type: Pathway
id: P00025
name: funnel_guaiacol
funneling branch: coniferyl branch
pathway component: vanillic acid → guaiacol
pathway component: guaiacol → catechol
pathway order: BiochemicalPathwayStep
  step conversion: vanillic acid → guaiacol
  reac id: R00074
  step order: 1
  next step: guaiacol → catechol
pathway order: BiochemicalPathwayStep
  step conversion: guaiacol → catechol
  reac id: R00073
  step order: 2
connections: beta-ketoadipate (all branches)
  type: PathwayConnection
  direction: downstream
  id: P00001
  pathway type: Fission
  connecting substrate id: S00001
connections: beta-ketoadipate: Catechol branch
  type: PathwayConnection
  direction: downstream
  id: P00009
  pathway type: Fission
  connecting substrate id: S00001
connections: catechol meta-cleavage
  type: PathwayConnection
  direction: downstream
  id: P00011
  pathway type: Fission
  connecting substrate id: S00001
created: 2026-02-28T10:42:00.406109+00:00
elignin note: This file is JSON-LD based on BioPAX Level 3 naming conventions. It is NOT a standards-compliant BioPAX OWL/RDF document. eLignin-specific extensions (elignin_id, connections, genes, …) are mapped to the http://www.elignindatabase.com/ontology# namespace. To convert to canonical BioPAX RDF/XML use pybiopax or a compatible RDF serialiser.

vanillic acid → guaiacol
type: BiochemicalReaction
id: R00074
left: vanillic acid
right: guaiacol
catalysis: Catalysis
  controller: non-oxidative vanillate decarboxylase
  controlled: vanillic acid → guaiacol

vanillic acid
type: SmallMolecule
id: S00006
chemical formula: C8H8O4
molecular weight: 168.15
xref: UnificationXref
  db: PubChem Compound
  id: 8468
xref: UnificationXref
  db: ChEBI
  id: 30816
xref: UnificationXref
  db: KEGG Compound
  id: C06672
xref: UnificationXref
  db: CAS
  id: 121-34-6

guaiacol
type: SmallMolecule
id: S00032
chemical formula: C7H8O2
molecular weight: 124.14
xref: UnificationXref
  db: PubChem Compound
  id: 460
xref: UnificationXref
  db: ChEBI
  id: 28591
xref: UnificationXref
  db: KEGG Compound
  id: C01502
xref: UnificationXref
  db: CAS
  id: 90-05-01
xref: UnificationXref
  db: PubChem Compound
  id: 460
xref: UnificationXref
  db: ChEBI
  id: 28591
xref: UnificationXref
  db: KEGG Compound
  id: C01502
xref: UnificationXref
  db: CAS
  id: 90-05-01
xref: UnificationXref
  db: PubChem Compound
  id: 460
xref: UnificationXref
  db: ChEBI
  id: 28591
xref: UnificationXref
  db: KEGG Compound
  id: C01502
xref: UnificationXref
  db: CAS
  id: 90-05-01

non-oxidative vanillate decarboxylase
type: Protein
id: E00060

guaiacol → catechol
type: BiochemicalReaction
id: R00073
left: guaiacol
right: catechol
catalysis: Catalysis
  controller: P450 aryl-O-demethylase
  controlled: guaiacol → catechol

catechol
type: SmallMolecule
id: S00001
chemical formula: C6H6O2
molecular weight: 110.11
xref: UnificationXref
  db: PubChem Compound
  id: 289
xref: UnificationXref
  db: ChEBI
  id: 18135
xref: UnificationXref
  db: KEGG Compound
  id: C00090
xref: UnificationXref
  db: CAS
  id: 120-80-9
xref: UnificationXref
  db: PubChem Compound
  id: 289
xref: UnificationXref
  db: ChEBI
  id: 18135
xref: UnificationXref
  db: KEGG Compound
  id: C00090
xref: UnificationXref
  db: CAS
  id: 120-80-9

P450 aryl-O-demethylase
type: Protein
id: E00059