The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

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Fission pathway: catechol meta-cleavage

Full Name
catechol meta-cleavage
Funneling Branch
catechol meta-cleavage branch

Pathway Network Visualization 📥 Export BioPAX JSON-LD

Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Cupriavidus necator JMP134 Pérez-Pantoja et al (2008)
Treponema primitia ZAS-1 Lucey et al (2013)
Pseudomonas putida mt-2 Murray et al (1972)
Cupriavidus necator ATCC 17697 Hughes et al (1983)
Burkholderia cepacia ATCC 29351 Hamzah et al (1994)
Pseudomonas fluorescens PU1 Mahiudddin et al (2012)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 catechol Bache et al (1981)
Acinetobacter baylyi ADP1 catechol Collier et al (1997)
Acinetobacter junii 5ga catechol González et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) catechol Davis et al (2012), Pometto III et al (1981), Antai et al (1983), Barton et al (2018)
Azotobacter vinelandii ATCC 12837 catechol Groseclose et al (1981)
Burkholderia cepacia KK01 catechol Kato et al (1998)
Burkholderia cepacia Song isolate 1 catechol Song (2009)
Candida albicans CBS562 catechol Gérecová et al (2015)
Candida dubliniensis CBS7987 catechol Gérecová et al (2015)
Candida maltosa Fialova isolate catechol Fialová et al (2004)
Candida tropicalis CBS94 catechol Gérecová et al (2015)
Candida tropicalis HP15 catechol Krug et al (1985)
Corynebacterium glutamicum ATCC13032 catechol Qi et al (2007)
Cryptococcus terreus PB4 catechol Bergauer et al (2005)
Cupriavidus laharis 1263a catechol Sato et al (2006)
Cupriavidus pinatubonensis 1245 catechol Sato et al (2006)
Desulfobacterium catecholicum NZva20 catechol Szewzyk et al (1987)
Exophiala jeanselmei CBS 658.76 catechol Middelhoven (1993)
Flavimonas oryzihabitans Song isolate 4 catechol Song (2009)
Fusarium oxysporum 4287 catechol Michielse et al (2012)
Leucosporidium scottii G43 catechol Middelhoven (1993)
Mastigobasidium intermedium PB8 catechol Bergauer et al (2005)
Microbacterium esteraromaticum Song isolate 5 catechol Song (2009)
Microbotryomycetidae sp. AG15 catechol Bergauer et al (2005)
Paenibacillus glucanolyticus SLM1 catechol Mathews et al (2014)
Pantoea dispersa Song isolate 2 catechol Song (2009)
Papillibacter cinnamivorans CIN1 catechol Defnoun et al (2000)
Pseudomonas fluorescens AN103 catechol Paulsen et al (2005)
Pseudomonas putida KT2440 catechol Jiménez et al (2002)
Pseudomonas putida Perestelo isolate 3 catechol Perestelo et al (1996)
Pseudomonas sp. MT1 catechol Pelz et al (1999)
Rhodococcus erythropolis 1CP catechol Eulberg et al (1997)
Rhodococcus erythropolis TA421 catechol Chung et al (1994)
Rhodococcus fascians AY730713 catechol Song (2009)
Rhodococcus fascians Song isolate 3 catechol Song (2009)
Rhodococcus jostii RHA1 catechol Kasai et al (2015)
Rhodosporidium lusitaniae PB14 catechol Bergauer et al (2005)
Rhodotorula creatinivora PB7 catechol Bergauer et al (2005)
Rhodotorula graminis WP1 catechol Durham et al (1984)
Rhodotorula vanillica IGC 4506 catechol Sampaio (1995)
Sporobolomyces roseus AG13 catechol Bergauer et al (2005)
Thauera sp. Cin3,4 catechol Mechichi et al (2005)
Trichosporon cutaneum CBS2466 catechol Middelhoven (1993)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Cupriavidus necator JMP134 2-hydroxymuconate-6-semialdehyde hydrolase Pérez-Pantoja et al (2008)
Treponema primitia ZAS-1 2-hydroxymuconate-6-semialdehyde hydrolase Lucey et al (2013)
Cupriavidus necator ATCC 17697 2-hydroxymuconate-6-semialdehyde hydrolase Hughes et al (1983)
Burkholderia cepacia ATCC 29351 2-hydroxymuconate-6-semialdehyde hydrolase Hamzah et al (1994)
Pseudomonas fluorescens PU1 2-hydroxymuconate-6-semialdehyde hydrolase Mahiudddin et al (2012)
Cupriavidus necator JMP134 2-oxopent-4-enoate hydratase Pérez-Pantoja et al (2008)
Treponema primitia ZAS-1 2-oxopent-4-enoate hydratase Lucey et al (2013)
Pseudomonas putida mt-2 2-oxopent-4-enoate hydratase Murray et al (1972)
Cupriavidus necator ATCC 17697 2-oxopent-4-enoate hydratase Hughes et al (1983)
Burkholderia cepacia ATCC 29351 2-oxopent-4-enoate hydratase Hamzah et al (1994)
Pseudomonas fluorescens PU1 2-oxopent-4-enoate hydratase Mahiudddin et al (2012)
Cupriavidus necator JMP134 4-hydroxy-2-oxovalerate aldolase Pérez-Pantoja et al (2008)
Treponema primitia ZAS-1 4-hydroxy-2-oxovalerate aldolase Lucey et al (2013)
Pseudomonas putida mt-2 4-hydroxy-2-oxovalerate aldolase Murray et al (1972)
Cupriavidus necator ATCC 17697 4-hydroxy-2-oxovalerate aldolase Hughes et al (1983)
Burkholderia cepacia ATCC 29351 4-hydroxy-2-oxovalerate aldolase Hamzah et al (1994)
Pseudomonas fluorescens PU1 4-hydroxy-2-oxovalerate aldolase Mahiudddin et al (2012)
Cupriavidus necator JMP134 catechol 2,3-dioxygenase Pérez-Pantoja et al (2008)
Treponema primitia ZAS-1 catechol 2,3-dioxygenase Lucey et al (2013)
Cupriavidus necator ATCC 17697 catechol 2,3-dioxygenase Hughes et al (1983)
Burkholderia cepacia ATCC 29351 catechol 2,3-dioxygenase Hamzah et al (1994)
Pseudomonas fluorescens PU1 catechol 2,3-dioxygenase Mahiudddin et al (2012)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 catechol → (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate catechol 2,3-dioxygenase R00027
2 (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate → 2-oxopent-4-enoate + Formic acid 2-hydroxymuconate-6-semialdehyde hydrolase R00028
3 2-oxopent-4-enoate → 4-hydroxy-2-oxopentanoate 2-oxopent-4-enoate hydratase R00029
4 4-hydroxy-2-oxopentanoate → acetaldehyde + pyruvate 4-hydroxy-2-oxovalerate aldolase R00030
5 acetaldehyde → acetyl-CoA - R00031

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
catechol C6H6O2 C1=CC=C(C(=C1)O)O 289 substrate
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate (intermediate) C6H5O4- C(=CC(=O)C(=O)O)C=C[O-] 70678568 product, substrate
2-oxopent-4-enoate (intermediate) C5H5O3- C=CCC(=O)C(=O)[O-] 9543147 product, substrate
Formic acid (intermediate) CH2O2 C(=O)O 284 product
4-hydroxy-2-oxopentanoate (intermediate) C5H7O4- CC(CC(=O)C(=O)[O-])O 9543038 product, substrate
acetaldehyde (intermediate) C2H4O CC=O 177 product, substrate
pyruvate (intermediate) C3H3O3- CC(=O)C(=O)[O-] 107735 product
acetyl-CoA (intermediate) C23H38N7O17P3S CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O 444493 product

Connected Pathways

Incoming Connections (Pathways connecting to this one:)

Source Pathway Connecting Compound
Funneling pathway: phenol catechol
Funneling pathway: benzoic acid catechol
Funneling pathway: salicylic acid I catechol
Funneling pathway: guaiacol catechol

Genes

Gene Enzyme
Cn_xylE catechol 2,3-dioxygenase
Cn_dmpB catechol 2,3-dioxygenase
Ppmt2_xylE catechol 2,3-dioxygenase
Ppmt2_xylG 2-hydroxymuconate-6-semialdehyde hydrolase
CNE_BB1p11950 4-hydroxy-2-oxovalerate aldolase
CNE_BB1p13240 4-hydroxy-2-oxovalerate aldolase
CNE_1c17880 4-hydroxy-2-oxovalerate aldolase
Cn_mhpE 4-hydroxy-2-oxovalerate aldolase
Cn_bpHI 4-hydroxy-2-oxovalerate aldolase

Other Databases

Database Comment
MetaCyc Metabolic pathway database

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