The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

brinkdp/eLignin 0 0

Funneling pathway: ferulic acid

Full Name
ferulic acid
Funneling Branch
coniferyl branch
Gene Ontology
GO:1901067

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Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Sphingobium sp. SYK-6 Masai et al (2002)
Pseudomonas putida KT2440 Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 Shen et al (2012)
Rhodotorula rubra IFO 889 Huang et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) Sutherland et al (1983)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 ferulic acid Bache et al (1981)
Acinetobacter baylyi ADP1 ferulic acid Salvachúa et al (2015), Fischer et al (2008)
Acinetobacter calcoaceticus DSM 586 ferulic acid Delneri et al (1995)
Aeromonas sp. L17 ferulic acid Deschamps et al (1980)
Azotobacter vinelandii NBRC13581 ferulic acid Hirose et al (2013)
Brettanomyces anomalus NCYC 615 ferulic acid Edlin et al (1995)
Clostridium methoxybenzovorans SR3 ferulic acid Mechichi et al (2005)
Comamonas sp. B-9 (CGMCC No. 4251) ferulic acid Chen et al (2012)
Cupriavidus necator JMP134 ferulic acid Pérez-Pantoja et al (2008)
Desulfobacterium phenolicum Ph01 ferulic acid Bak et al (1986)
Enterobacter aerogenes L7 ferulic acid Deschamps et al (1980)
Enterobacter sp. DG-6 ferulic acid Grbić-Galić (1985)
Exophiala jeanselmei CBS 658.76 ferulic acid Middelhoven (1993)
Flavobacterium lutescens NBRC3084 ferulic acid Hirose et al (2013)
Fusarium oxysporum 4287 ferulic acid Michielse et al (2012)
Fusarium oxysporum MUCL 30736 ferulic acid Falcón et al (1995)
Fusarium solani MUCL 35071 ferulic acid Falcón et al (1995)
Holophaga foetida TMBS4 ferulic acid Bak et al (1993)
Leucosporidium scottii G43 ferulic acid Middelhoven (1993)
Marinobacterium georgiense KW-40 ferulic acid GONZaLEZ et al (1997)
Microbulbifer hydrolyticus IRE-31 ferulic acid GONZaLEZ et al (1997)
Oceanimonas doudoroffii JCM21046T ferulic acid Numata et al (2015)
Paraburkholderia aromaticivorans AR20-38 ferulic acid Margesin et al (2021)
Penicillium chrysogenum MUCL 31363 ferulic acid Rodríguez et al (1994), Falcón et al (1995)
Pestalotia oxyanthi MUCL 35070 ferulic acid Falcón et al (1995)
Pseudomonas fluorescens AN103 ferulic acid Narbad et al (1998)
Pseudomonas mira V2 ferulic acid Jurková et al (1993)
Pseudomonas putida F1 ferulic acid Hirose et al (2013)
Pseudomonas putida Perestelo isolate 3 ferulic acid Perestelo et al (1996)
Pseudomonas sp. HR199 ferulic acid Overhage et al (1999)
Pseudomonas sp. Isolate 9.1 ferulic acid Ravi et al (2018)
Pseudomonas sp. KF704 ferulic acid Hirose et al (2013)
Rhizobium sp. YS-1r ferulic acid Jackson et al (2017)
Rhodococcus jostii RHA1 ferulic acid Sainsbury et al (2013)
Rhodopseudomonas palustris CGA001 ferulic acid Harwood et al (1988)
Rhodopseudomonas palustris CGA009 ferulic acid Salmon et al (2013)
Rhodosporidiobolus colostri DBVPG 10655 ferulic acid Margesin et al (2022)
Rhodosporidium toruloides IFO0880 ferulic acid Yaegashi et al (2017)
Rhodotorula sp. R2 ferulic acid Hainal et al (2012)
Rhodotorula mucilaginosa CBS17 ferulic acid Sampaio (1999)
Rhodotorula vanillica IGC 4506 ferulic acid Sampaio (1995)
Sphingomonas aromaticivorans F199 ferulic acid Cecil et al (2018)
Thermomonospora mesophila DSM 43048 ferulic acid McCarthy et al (1984)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

Organism Strain Predicted enzyme Reference confirming pathway
Corynebacterium glutamicum ATCC13032 Feruloyl-CoA synthase Shen et al (2012)
Rhodotorula rubra IFO 889 Feruloyl-CoA synthase Huang et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) Feruloyl-CoA synthase Sutherland et al (1983)
Pseudomonas putida KT2440 trans-feruloyl-CoA hydratase Jiménez et al (2002)
Corynebacterium glutamicum ATCC13032 trans-feruloyl-CoA hydratase Shen et al (2012)
Rhodotorula rubra IFO 889 trans-feruloyl-CoA hydratase Huang et al (1993)
Amycolatopsis sp. 75iv2 (ATCC 39116) trans-feruloyl-CoA hydratase Sutherland et al (1983)

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 ferulic acid + coenzyme A → feruloyl-CoA Feruloyl-CoA synthase R00020
2 feruloyl-CoA → 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA trans-feruloyl-CoA hydratase R00021
3 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA → acetyl-CoA + vanillin trans-feruloyl-CoA hydratase R00025

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
ferulic acid C10H10O4 COC1=C(C=CC(=C1)C=CC(=O)O)O 445858 substrate
coenzyme A (intermediate) C21H36N7O16P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCS)O 87642 substrate
feruloyl-CoA (intermediate) C31H44N7O19P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C=CC4=CC(=C(C=C4)O)OC)O 139031281 product, substrate
4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA (intermediate) C31H46N7O20P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(C4=CC(=C(C=C4)O)OC)O)O 11966199 product, substrate
acetyl-CoA (intermediate) C23H38N7O17P3S CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O 444493 product
vanillin C8H8O3 COC1=C(C=CC(=C1)C=O)O 1183 product

Connected Pathways

Outgoing Connections (This pathway connects to:)

Connected Pathway Connecting Compound
Funneling pathway: vanillin I vanillin
Funneling pathway: vanillin II vanillin

Incoming Connections (Pathways connecting to this one:)

Source Pathway Connecting Compound
- ferulic acid
Funneling pathway: coniferyl alcohol ferulic acid

Genes

Gene Enzyme
Pp_fcs Feruloyl-CoA synthase
Sph_ferA Feruloyl-CoA synthase
Sph_ferB trans-feruloyl-CoA hydratase
Sph_ferB2 trans-feruloyl-CoA hydratase

Other Databases

Database Comment
MetaCyc Metabolic pathway database

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