The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

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vanillin

Compound Overview

Name vanillin
IUPAC Name 4-hydroxy-3-methoxybenzaldehyde
Formula C8H8O3
SMILES COC1=C(C=CC(=C1)C=O)O
Carbon Number 8
Molecular Weight 152.15
Polymer Type monomer
Synonyms 4-hydroxy-3-methoxybenzaldehyde
4-formyl-2-methoxyphenol
3-methoxy-4-hydroxybenzaldehyde
4-hydroxy-m-anisaldehyde
methylprotocatechuic aldehyde
p-hydroxy-m-methoxybenzaldehyde
vanillaldehyde
vanillic aldehyde

Chemical Structure

Chemical structure of vanillin

Structure from PubChem

External Databases

CAS 121-33-5
PubChem 1183
KEGG C00755
ChEBI 18346
Empirical Data

Organisms that can utilize this substrate (41) Empirical

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Organism ▲ ▼ Strain ▲ ▼ Reference ▲ ▼ Comment ▲ ▼
Amycolatopsis sp. 75iv2 (ATCC 39116) Davis et al (2012), Sutherland et al (1983) -
Pseudomonas fluorescens AN103 Narbad et al (1998) -
Phanerochaete chrysosporium ATCC 34541 Nakamura et al (2011) -
Pseudomonas fluorescens DSM 50090 Ravi et al (2018) -
Pseudomonas putida F1 Hirose et al (2013) -
Pseudomonas sp. HR199 Overhage et al (1999) -
Pseudomonas sp. Isolate 9.1 Ravi et al (2018) -
Serratia sp. JHT01 Tian et al (2016) -
Bacillus licheniformis KB1 Kuhnigk et al (1997) -
Alcaligenes faecalis KD10 Kuhnigk et al (1997) -
Nocardia sp. KD19 Kuhnigk et al (1997) -
Bacillus cereus KD4 Kuhnigk et al (1997) -
Bacillus subtilis KD8 Kuhnigk et al (1997) -
Burkholderia cepacia KF12 Kuhnigk et al (1997) -
Pseudomonas sp. KF704 Hirose et al (2013) -
Pseudomonas citronellolis KMA4 Kuhnigk et al (1997) -
Acinetobacter baumannii KMB1 Kuhnigk et al (1997) -
Pseudomonas aeruginosa KMD3 Kuhnigk et al (1997) -
Comamonas acidovorans KNB3 Kuhnigk et al (1997) -
Pseudomonas putida KT2440 Ravi et al (2017) -
Pandoraea norimbergensis LD001 Bandounas et al (2011) -
Pseudomonas sp. LLC-1 Hirose et al (2013), Hirose et al (2020) -
Ochrobactrum sp. LLC-2 Hirose et al (2013) -
Klebsiella sp. LLC-3 Hirose et al (2013) -
Penicillium chrysogenum MUCL 31363 Rodríguez et al (1994) -
Azotobacter vinelandii NBRC13581 Hirose et al (2013) -
Flavobacterium lutescens NBRC3084 Hirose et al (2013) -
Brettanomyces anomalus NCYC 615 Edlin et al (1995) -
Acetobacterium woodii NZva16 Bache et al (1981) (anaerobically)
Serratia liquefaciens sp. PT01 Tian et al (2016) -
Pseudomonas chlororaphis subsp. aureofaciens PT02 Tian et al (2016) -
Serratia marcescens Perestelo isolate 2 Perestelo et al (1989) -
Pseudomonas putida Perestelo isolate 3 Perestelo et al (1996) -
Rhodococcus jostii RHA1 Chen et al (2012) -
Paenibacillus glucanolyticus SLM1 Mathews et al (2014) -
Clostridium methoxybenzovorans SR3 Mechichi et al (2005) (anaerobically)
Sphingobium sp. SYK-6 MASAI et al (2007) -
Streptomyces viridosporus T7A Pometto et al (1983) -
Rhodococcus sp. UKMP-5M Azman (2015) -
Citrobacter sp. VA53 HARAZONO et al (2003) -
Burkholderia sp. VE22 HARAZONO et al (2003) -

Pathways Empirical

Pathway Name Full Name
vanillin I vanillin I
vanillin II vanillin II
ferulic acid ferulic acid
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted to process vanillin through a pathway Predicted

For each pathway where vanillin enters as a reactant, organisms recorded as being able to utilise it but not yet confirmed for that pathway are listed as predicted. Not experimentally verified. What does this mean?

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Organism Strain Inferred via pathway Reference confirming vanillin utilization
Acetobacterium woodii NZva16 vanillin I Bache et al (1981)
Acinetobacter baumannii KMB1 vanillin I Kuhnigk et al (1997)
Alcaligenes faecalis KD10 vanillin I Kuhnigk et al (1997)
Amycolatopsis sp. 75iv2 (ATCC 39116) vanillin I Davis et al (2012), Sutherland et al (1983)
Azotobacter vinelandii NBRC13581 vanillin I Hirose et al (2013)
Bacillus cereus KD4 vanillin I Kuhnigk et al (1997)
Bacillus licheniformis KB1 vanillin I Kuhnigk et al (1997)
Bacillus subtilis KD8 vanillin I Kuhnigk et al (1997)
Brettanomyces anomalus NCYC 615 vanillin I Edlin et al (1995)
Burkholderia cepacia KF12 vanillin I Kuhnigk et al (1997)
Burkholderia sp. VE22 vanillin I HARAZONO et al (2003)
Citrobacter sp. VA53 vanillin I HARAZONO et al (2003)
Clostridium methoxybenzovorans SR3 vanillin I Mechichi et al (2005)
Comamonas acidovorans KNB3 vanillin I Kuhnigk et al (1997)
Flavobacterium lutescens NBRC3084 vanillin I Hirose et al (2013)
Klebsiella sp. LLC-3 vanillin I Hirose et al (2013)
Nocardia sp. KD19 vanillin I Kuhnigk et al (1997)
Ochrobactrum sp. LLC-2 vanillin I Hirose et al (2013)
Paenibacillus glucanolyticus SLM1 vanillin I Mathews et al (2014)
Pandoraea norimbergensis LD001 vanillin I Bandounas et al (2011)
Penicillium chrysogenum MUCL 31363 vanillin I Rodríguez et al (1994)
Phanerochaete chrysosporium ATCC 34541 vanillin I Nakamura et al (2011)
Pseudomonas aeruginosa KMD3 vanillin I Kuhnigk et al (1997)
Pseudomonas chlororaphis subsp. aureofaciens PT02 vanillin I Tian et al (2016)
Pseudomonas citronellolis KMA4 vanillin I Kuhnigk et al (1997)
Pseudomonas fluorescens AN103 vanillin I Narbad et al (1998)
Pseudomonas fluorescens DSM 50090 vanillin I Ravi et al (2018)
Pseudomonas putida F1 vanillin I Hirose et al (2013)
Pseudomonas putida KT2440 vanillin I Ravi et al (2017)
Pseudomonas putida Perestelo isolate 3 vanillin I Perestelo et al (1996)
Pseudomonas sp. HR199 vanillin I Overhage et al (1999)
Pseudomonas sp. Isolate 9.1 vanillin I Ravi et al (2018)
Pseudomonas sp. KF704 vanillin I Hirose et al (2013)
Pseudomonas sp. LLC-1 vanillin I Hirose et al (2013), Hirose et al (2020)
Rhodococcus jostii RHA1 vanillin I Chen et al (2012)
Rhodococcus sp. UKMP-5M vanillin I Azman (2015)
Serratia liquefaciens sp. PT01 vanillin I Tian et al (2016)
Serratia marcescens Perestelo isolate 2 vanillin I Perestelo et al (1989)
Serratia sp. JHT01 vanillin I Tian et al (2016)
Streptomyces viridosporus T7A vanillin I Pometto et al (1983)
Acetobacterium woodii NZva16 vanillin II Bache et al (1981)
Acinetobacter baumannii KMB1 vanillin II Kuhnigk et al (1997)
Alcaligenes faecalis KD10 vanillin II Kuhnigk et al (1997)
Amycolatopsis sp. 75iv2 (ATCC 39116) vanillin II Davis et al (2012), Sutherland et al (1983)
Azotobacter vinelandii NBRC13581 vanillin II Hirose et al (2013)
Bacillus cereus KD4 vanillin II Kuhnigk et al (1997)
Bacillus licheniformis KB1 vanillin II Kuhnigk et al (1997)
Bacillus subtilis KD8 vanillin II Kuhnigk et al (1997)
Brettanomyces anomalus NCYC 615 vanillin II Edlin et al (1995)
Burkholderia cepacia KF12 vanillin II Kuhnigk et al (1997)
Burkholderia sp. VE22 vanillin II HARAZONO et al (2003)
Citrobacter sp. VA53 vanillin II HARAZONO et al (2003)
Clostridium methoxybenzovorans SR3 vanillin II Mechichi et al (2005)
Comamonas acidovorans KNB3 vanillin II Kuhnigk et al (1997)
Flavobacterium lutescens NBRC3084 vanillin II Hirose et al (2013)
Klebsiella sp. LLC-3 vanillin II Hirose et al (2013)
Nocardia sp. KD19 vanillin II Kuhnigk et al (1997)
Ochrobactrum sp. LLC-2 vanillin II Hirose et al (2013)
Paenibacillus glucanolyticus SLM1 vanillin II Mathews et al (2014)
Pandoraea norimbergensis LD001 vanillin II Bandounas et al (2011)
Penicillium chrysogenum MUCL 31363 vanillin II Rodríguez et al (1994)
Phanerochaete chrysosporium ATCC 34541 vanillin II Nakamura et al (2011)
Pseudomonas aeruginosa KMD3 vanillin II Kuhnigk et al (1997)
Pseudomonas chlororaphis subsp. aureofaciens PT02 vanillin II Tian et al (2016)
Pseudomonas citronellolis KMA4 vanillin II Kuhnigk et al (1997)
Pseudomonas fluorescens AN103 vanillin II Narbad et al (1998)
Pseudomonas fluorescens DSM 50090 vanillin II Ravi et al (2018)
Pseudomonas putida F1 vanillin II Hirose et al (2013)
Pseudomonas putida KT2440 vanillin II Ravi et al (2017)
Pseudomonas putida Perestelo isolate 3 vanillin II Perestelo et al (1996)
Pseudomonas sp. HR199 vanillin II Overhage et al (1999)
Pseudomonas sp. Isolate 9.1 vanillin II Ravi et al (2018)
Pseudomonas sp. KF704 vanillin II Hirose et al (2013)
Pseudomonas sp. LLC-1 vanillin II Hirose et al (2013), Hirose et al (2020)
Rhodococcus jostii RHA1 vanillin II Chen et al (2012)
Rhodococcus sp. UKMP-5M vanillin II Azman (2015)
Serratia liquefaciens sp. PT01 vanillin II Tian et al (2016)
Serratia marcescens Perestelo isolate 2 vanillin II Perestelo et al (1989)
Serratia sp. JHT01 vanillin II Tian et al (2016)
Sphingobium sp. SYK-6 vanillin II MASAI et al (2007)
Streptomyces viridosporus T7A vanillin II Pometto et al (1983)

Reactions involving vanillin

Reaction Role in Reaction
Vanillin + NAD+ + H2O → Vanillic acid + NADH + 2H+ substrate
4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA → Acetyl-CoA + Vanillin product

Transporters

No transporters are currently linked to this substrate.

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