The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

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3-hydroxybenzoic acid

Compound Overview

Name 3-hydroxybenzoic acid
IUPAC Name 3-hydroxybenzoic acid
Formula C7H6O3
SMILES C1=CC(=CC(=C1)O)C(=O)O
Carbon Number 7
Molecular Weight 138.12
Polymer Type monomer
Synonyms 3-carboxyphenol
m-Hydroxybenzoic acid
m-salicylic acid
3-hydroxybenzoate
m-hydroxybenzote

Chemical Structure

Chemical structure of 3-hydroxybenzoic acid

Structure from PubChem

External Databases

CAS 99-06-9
PubChem 7420
KEGG C00587
ChEBI 30764
Empirical Data

Organisms that can utilize this substrate (17) Empirical

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Organism ▲ ▼ Strain ▲ ▼ Reference ▲ ▼ Comment ▲ ▼
Amycolatopsis sp. 75iv2 (ATCC 39116) Pometto III et al (1981) -
Corynebacterium glutamicum ATCC13032 Shen et al (2005) -
Comamonas testosteroni BR6020 Providenti et al (2001) -
Exophiala jeanselmei CBS 658.76 Middelhoven (1993) -
Rhodotorula mucilaginosa CBS17 Sampaio (1999) -
Trichosporon cutaneum CBS2466 Middelhoven (1993) -
Candida parapsilosis CBS604 Middelhoven et al (1992), Gérecová et al (2015) -
Rhodopseudomonas palustris CGA001 Harwood et al (1988), Harwood et al (1988) (anaerobically)
Comamonas testosteroni CNB-1 Ni et al (2012) -
Thauera sp. Cin3,4 Mechichi et al (2005) (anaerobically)
Leucosporidium scottii G43 Middelhoven (1993) -
Oceanimonas doudoroffii JCM21046T Numata et al (2015) -
Thauera aromatica K172 Mechichi et al (2002) (anaerobically)
Azoarcus anaerobius LuFRes1 Gorny et al (1992) (anaerobically)
Klebsiella pneumoniae M5a1 Jones et al (1990) -
Novosphingobium taihuense T3-B9 Liu et al (2005) -
Rhodotorula graminis WP1 Durham et al (1984) -

Pathways Empirical

Pathway Name Full Name
m-cresol m-cresol
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted to process 3-hydroxybenzoic acid through a pathway Predicted

For each pathway where 3-hydroxybenzoic acid enters as a reactant, organisms recorded as being able to utilise it but not yet confirmed for that pathway are listed as predicted. Not experimentally verified. What does this mean?

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Organism Strain Inferred via pathway Reference confirming 3-hydroxybenzoic acid utilization
Amycolatopsis sp. 75iv2 (ATCC 39116) m-cresol Pometto III et al (1981)
Azoarcus anaerobius LuFRes1 m-cresol Gorny et al (1992)
Candida parapsilosis CBS604 m-cresol Middelhoven et al (1992), Gérecová et al (2015)
Comamonas testosteroni BR6020 m-cresol Providenti et al (2001)
Comamonas testosteroni CNB-1 m-cresol Ni et al (2012)
Corynebacterium glutamicum ATCC13032 m-cresol Shen et al (2005)
Exophiala jeanselmei CBS 658.76 m-cresol Middelhoven (1993)
Klebsiella pneumoniae M5a1 m-cresol Jones et al (1990)
Leucosporidium scottii G43 m-cresol Middelhoven (1993)
Novosphingobium taihuense T3-B9 m-cresol Liu et al (2005)
Oceanimonas doudoroffii JCM21046T m-cresol Numata et al (2015)
Rhodopseudomonas palustris CGA001 m-cresol Harwood et al (1988)
Rhodotorula graminis WP1 m-cresol Durham et al (1984)
Rhodotorula mucilaginosa CBS17 m-cresol Sampaio (1999)
Thauera aromatica K172 m-cresol Mechichi et al (2002)
Thauera sp. Cin3,4 m-cresol Mechichi et al (2005)
Trichosporon cutaneum CBS2466 m-cresol Middelhoven (1993)

Reactions involving 3-hydroxybenzoic acid

Reaction Role in Reaction
3-hydroxybenzoic acid + NADH + oxygen + H+ → gentisic acid + NAD+ + H2O substrate
3-hydroxybenzaldehyde + NADP+ + H2O → 3-hydroxybenzoate + NADPH + 2 H+ product
3-hydroxybenzoic acid + NADPH + oxygen + H+ → protocatechuic acid + NADP+ + H2O substrate

Transporters

Transporter Reference
Kp_MhbTp Xu et al (2012)

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