The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

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4-cresol

Compound Overview

Name 4-cresol
IUPAC Name 4-methylphenol
Formula C7H8O
SMILES CC1=CC=C(C=C1)O
Carbon Number 7
Molecular Weight 108.14
Polymer Type monomer
Synonyms p-cresol
4-Hydroxytoluene
p-Methylphenol
p-tolyl alcohol
1-hydroxy-4-methylbenzene
4-methylphenol

Chemical Structure

Chemical structure of 4-cresol

Structure from PubChem

External Databases

CAS 106-44-5
PubChem 2879
KEGG C01468
ChEBI 17847
Empirical Data

Organisms that can utilize this substrate (17) Empirical

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Organism ▲ ▼ Strain ▲ ▼ Reference ▲ ▼ Comment ▲ ▼
Rhodococcus erythropolis A5.1 Taylor et al (2012) -
Azotobacter vinelandii ATCC 12837 Groseclose et al (1981) -
Cupriavidus necator ATCC 17697 Hughes et al (1983) -
Corynebacterium glutamicum ATCC13032 Qi et al (2007) -
Exophiala jeanselmei CBS 658.76 Middelhoven (1993) -
Thauera sp. Cin3,4 Mechichi et al (2005) -
Micrococcus luteus E1.1 Taylor et al (2012) -
Aromatoleum aromaticum EbN1 Wöhlbrand et al (2007) (anaerobically)
Sphingomonas aromaticivorans F199 BALKWILL et al (1997) -
Thauera aromatica K172 Tschech et al (1987), Tschech et al (1987) (anaerobically)
(anaerobically)
Burkholderia cepacia KK01 Kato et al (1998) -
Azoarcus anaerobius LuFRes1 Gorny et al (1992) (anaerobically)
Pseudomonas putida NCIMB 9866 Cronin et al (1999) -
Rhodotorula creatinivora PB7 Bergauer et al (2005) -
Desulfobacterium phenolicum Ph01 Bak et al (1986) (anaerobically)
Rhodococcus jostii RHA1 Otani et al (2014) -
Trametes versicolor Strain 1 Alexieva et al (2010) -

Pathways Empirical

Pathway Name Full Name
p-cresol p-cresol
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted to process 4-cresol through a pathway Predicted

For each pathway where 4-cresol enters as a reactant, organisms recorded as being able to utilise it but not yet confirmed for that pathway are listed as predicted. Not experimentally verified. What does this mean?

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Organism Strain Inferred via pathway Reference confirming 4-cresol utilization
Aromatoleum aromaticum EbN1 p-cresol Wöhlbrand et al (2007)
Azoarcus anaerobius LuFRes1 p-cresol Gorny et al (1992)
Azotobacter vinelandii ATCC 12837 p-cresol Groseclose et al (1981)
Burkholderia cepacia KK01 p-cresol Kato et al (1998)
Corynebacterium glutamicum ATCC13032 p-cresol Qi et al (2007)
Cupriavidus necator ATCC 17697 p-cresol Hughes et al (1983)
Desulfobacterium phenolicum Ph01 p-cresol Bak et al (1986)
Exophiala jeanselmei CBS 658.76 p-cresol Middelhoven (1993)
Micrococcus luteus E1.1 p-cresol Taylor et al (2012)
Rhodococcus erythropolis A5.1 p-cresol Taylor et al (2012)
Rhodococcus jostii RHA1 p-cresol Otani et al (2014)
Rhodotorula creatinivora PB7 p-cresol Bergauer et al (2005)
Sphingomonas aromaticivorans F199 p-cresol BALKWILL et al (1997)
Thauera aromatica K172 p-cresol Tschech et al (1987)
Thauera sp. Cin3,4 p-cresol Mechichi et al (2005)
Trametes versicolor Strain 1 p-cresol Alexieva et al (2010)

Reactions involving 4-cresol

Reaction Role in Reaction
p-cresol + 2 azurin (oxidized) + H2O → 4-hydroxybenzyl alcohol + 2 azurin (reduced) + 2 H+ substrate

Transporters

No transporters are currently linked to this substrate.

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