The eLignin Microbial Database

A curated resource for microbial metabolism of lignin-derived aromatic compounds

brinkdp/eLignin 0 0

Funneling pathway: salicylic acid II

Full Name
salicylic acid II
Funneling Branch
gentisate branch

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Interactive metabolic pathway map showing compounds (text labels) connected by reaction arrows. Click arrows to view reaction details, click compounds to view substrate details. Zoom with mouse wheel, pan by dragging.

Empirical Data

Organisms with this Pathway Empirical

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Organism Strain Reference(s)
Streptomyces sp. WA46 Ishiyama et al (2004)
Predicted Relationships Hide predicted
The sections below contain relationships inferred from the empirical data above. They are computationally predicted and have not been independently verified. Learn more about data assumptions →
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Organisms predicted for this pathway Predicted

Inferred from reported substrate utilization: organisms that can utilise a compound entering this pathway as a reactant are predicted to carry the pathway, unless already confirmed. The reference confirming substrate use is shown. Not experimentally verified. What does this mean?

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Predicted organism Strain Inferred via substrate Reference
Acetobacterium woodii NZva16 salicylic acid Bache et al (1981)
Burkholderia cepacia ATCC 29351 salicylic acid Hamzah et al (1994)
Burkholderia cepacia KK01 salicylic acid Kato et al (1998)
Burkholderia cepacia Song isolate 1 salicylic acid Song (2009)
Cryptococcus terreus PB4 salicylic acid Bergauer et al (2005)
Cupriavidus pinatubonensis 1245 salicylic acid Sato et al (2006)
Desulfobacterium phenolicum Ph01 salicylic acid Bak et al (1986)
Exophiala jeanselmei CBS 658.76 salicylic acid Middelhoven (1993)
Leucosporidium scottii G43 salicylic acid Middelhoven (1993)
Pantoea dispersa Song isolate 2 salicylic acid Song (2009)
Rhodococcus fascians AY730713 salicylic acid Song (2009)
Rhodococcus fascians Song isolate 3 salicylic acid Song (2009)
Rhodococcus rhodochrous 116 salicylic acid Karlson et al (1993)
Rhodotorula creatinivora PB7 salicylic acid Bergauer et al (2005)
Rhodotorula graminis WP1 salicylic acid Durham et al (1984)
Rhodotorula ingeniosa PB5 salicylic acid Bergauer et al (2005)
Thauera aromatica K172 salicylic acid Mechichi et al (2002)

Predicted enzyme assignments for confirmed organisms Predicted

Inferred from confirmed pathway membership: if an organism is confirmed to carry this pathway, enzymes known to catalyse reactions within it are predicted to be present. The reference confirming the organism’s membership of this pathway is shown. Not experimentally verified. What does this mean?

No predicted enzyme assignments: all confirmed organisms are already linked to the enzymes of this pathway.

Reactions in this Pathway

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Order Substrates Products Enzyme(s) Reaction
1 salicylic acid → salicylate-adenylate salicylyl-CoA synthase / salicilate adenylyltransferase R00046
2 salicylate-adenylate → salicyloyl-CoA salicylyl-CoA synthase / salicilate adenylyltransferase R00047
3 salicyloyl-CoA → gentisyl-CoA salicylyl-CoA synthase R00048
4 gentisyl-CoA → gentisic acid salicylyl-CoA 5-hydroxylase R00049

Compounds (Substrates & Products)

Intermediate metabolites that are not registered in the Substrate table are shown as plain text without a hyperlink.

Compound Name Formula SMILES PubChem Role
salicylic acid C7H6O3 C1=CC=C(C(=C1)C(=O)O)O 338 substrate
salicylate-adenylate (intermediate) - - - product
salicylate-adenylate (intermediate) - - - substrate
salicyloyl-CoA (intermediate) C28H40N7O18P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=CC=CC=C4O)O 11966295 product, substrate
gentisyl-CoA (intermediate) C28H40N7O19P3S CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)C4=C(C=CC(=C4)O)O)O 49859680 product, substrate
gentisic acid C7H6O4 C1=CC(=C(C=C1O)C(=O)O)O 3469 product

Connected Pathways

Outgoing Connections (This pathway connects to:)

Connected Pathway Connecting Compound
Fission pathway: gentisate-cleavage gentisic acid

Genes

Gene Enzyme
Str_sdgA salicylyl-CoA synthase / salicilate adenylyltransferase
Str_sdgB salicylyl-CoA synthase
Str_sdgC salicylyl-CoA 5-hydroxylase

Other Databases

Database Comment
MetaCyc Metabolic pathway database

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