Funneling pathway: syringic acid III
type: Pathway
id: P00023
name: funnel_syringate_III
funneling branch: sinapyl branch
pathway component: syringic acid → 3-O-methylgallate
pathway component: 3-O-methylgallate → 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
pathway component: 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate → (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
pathway component: (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate → 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
pathway component: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate → pyruvate
pathway component: oxaloacetate → pyruvate
pathway order: BiochemicalPathwayStep
  step conversion: syringic acid → 3-O-methylgallate
  reac id: R00055
  step order: 1
  next step: 3-O-methylgallate → 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
pathway order: BiochemicalPathwayStep
  step conversion: 3-O-methylgallate → 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
  reac id: R00069
  step order: 2
  next step: 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate → (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
pathway order: BiochemicalPathwayStep
  step conversion: 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate → (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
  reac id: R00070
  step order: 3
  next step: (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate → 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
pathway order: BiochemicalPathwayStep
  step conversion: (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate → 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
  reac id: R00012
  step order: 4
  next step: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate → pyruvate
pathway order: BiochemicalPathwayStep
  step conversion: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate → pyruvate
  reac id: R00013
  step order: 5
  next step: oxaloacetate → pyruvate
pathway order: BiochemicalPathwayStep
  step conversion: oxaloacetate → pyruvate
  reac id: R00054
  step order: 6
created: 2026-02-28T10:42:00.477129+00:00
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syringic acid → 3-O-methylgallate
type: BiochemicalReaction
id: R00055
left: syringic acid
left: tetrahydrofolate
right: 3-O-methylgallate
catalysis: Catalysis
  controller: syringate O-demethylase
  controlled: syringic acid → 3-O-methylgallate
comment: Reaction shared between Syringate pathways I-II

syringic acid
type: SmallMolecule
id: S00035
chemical formula: C9H10O5
molecular weight: 198.17
xref: UnificationXref
  db: PubChem Compound
  id: 10742
xref: UnificationXref
  db: ChEBI
  id: 68329
xref: UnificationXref
  db: KEGG Compound
  id: C10833
xref: UnificationXref
  db: CAS
  id: 530-57-4

syringate O-demethylase
type: Protein
id: E00048
EC number: 2.1.1.341

3-O-methylgallate → 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
type: BiochemicalReaction
id: R00069
left: 3-O-methylgallate
right: 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
catalysis: Catalysis
  controller: 3-O-methylgallate 3,4-dioxygenase
  controlled: 3-O-methylgallate → 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate

3-O-methylgallate 3,4-dioxygenase
type: Protein
id: E00055

4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate → (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
type: BiochemicalReaction
id: R00070
left: 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
right: (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
comment: Hypothetical reaction

(1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate → 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
type: BiochemicalReaction
id: R00012
left: (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate
right: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
catalysis: Catalysis
  controller: 4-oxalmesaconate hydratase
  controlled: (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate → 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
comment: Reaction shared between Syringate pathways I-II

4-oxalmesaconate hydratase
type: Protein
id: E00058

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate → pyruvate
type: BiochemicalReaction
id: R00013
left: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
right: pyruvate
right: oxaloacetic acid
catalysis: Catalysis
  controller: oxaloacetate decarboxylase
  controlled: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate → pyruvate
catalysis: Catalysis
  controller: HMG aldolase
  controlled: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate → pyruvate
comment: Reaction shared between Syringate pathways I-II

oxaloacetate decarboxylase
type: Protein
id: E00046
EC number: EC 4.1.1.3

HMG aldolase
type: Protein
id: E00050

oxaloacetate → pyruvate
type: BiochemicalReaction
id: R00054
left: oxaloacetate
right: pyruvate
catalysis: Catalysis
  controller: oxaloacetate decarboxylase
  controlled: oxaloacetate → pyruvate
comment: Reaction shared between Syringate pathways I-II