Fission pathway: beta-ketoadipate pathway: Protocatechuate branch
type: Pathway
id: P00004
name: bketo_protoch
name: 3-oxoadipate pathway: protocatechuate branch
name: 3-ketoadipate pathway: protocatechuate branch
name: protocatechuate 3,4-cleavage pathway
name: protocatechuate ortho-cleavage pathway
funneling branch: beta-ketoadipate branch
pathway component: protocatechuic acid → 3-carboxy-cis,cis-muconate
pathway component: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
pathway component: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
pathway component: 3-oxoadipate enol lactone → beta-ketoadipate
pathway order: BiochemicalPathwayStep
  step conversion: protocatechuic acid → 3-carboxy-cis,cis-muconate
  reac id: R00016
  step order: 1
  next step: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
pathway order: BiochemicalPathwayStep
  step conversion: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
  reac id: R00017
  step order: 2
  next step: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
pathway order: BiochemicalPathwayStep
  step conversion: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
  reac id: R00018
  step order: 3
  next step: 3-oxoadipate enol lactone → beta-ketoadipate
pathway order: BiochemicalPathwayStep
  step conversion: 3-oxoadipate enol lactone → beta-ketoadipate
  reac id: R00019
  step order: 4
connections: beta-ketoadipate: lower branch
  type: PathwayConnection
  direction: downstream
  id: P00010
  pathway type: Fission
connections: vanillin I
  type: PathwayConnection
  direction: upstream
  id: P00006
  pathway type: Funneling
  connecting substrate id: S00002
connections: vanillin II
  type: PathwayConnection
  direction: upstream
  id: P00007
  pathway type: Funneling
  connecting substrate id: S00002
connections: p-coumaric acid
  type: PathwayConnection
  direction: upstream
  id: P00014
  pathway type: Funneling
  connecting substrate id: S00002
connections: caffeic acid
  type: PathwayConnection
  direction: upstream
  id: P00018
  pathway type: Funneling
  connecting substrate id: S00002
connections: m-cresol
  type: PathwayConnection
  direction: upstream
  id: P00021
  pathway type: Funneling
  connecting substrate id: S00002
connections: p-cresol
  type: PathwayConnection
  direction: upstream
  id: P00024
  pathway type: Funneling
  connecting substrate id: S00002
created: 2026-02-28T10:42:00.337795+00:00
elignin note: This file is JSON-LD based on BioPAX Level 3 naming conventions. It is NOT a standards-compliant BioPAX OWL/RDF document. eLignin-specific extensions (elignin_id, connections, genes, …) are mapped to the http://www.elignindatabase.com/ontology# namespace. To convert to canonical BioPAX RDF/XML use pybiopax or a compatible RDF serialiser.

protocatechuic acid → 3-carboxy-cis,cis-muconate
type: BiochemicalReaction
id: R00016
left: protocatechuic acid
right: 3-carboxy-cis,cis-muconate
catalysis: Catalysis
  controller: Protocatechuate 3,4-dioxygenase
  controlled: protocatechuic acid → 3-carboxy-cis,cis-muconate

protocatechuic acid
type: SmallMolecule
id: S00002
chemical formula: C7H6O4
molecular weight: 153.11
xref: UnificationXref
  db: PubChem Compound
  id: 72
xref: UnificationXref
  db: ChEBI
  id: 36062
xref: UnificationXref
  db: KEGG Compound
  id: C00230
xref: UnificationXref
  db: CAS
  id: 99-50-3

Protocatechuate 3,4-dioxygenase
type: Protein
id: E00011
EC number: 1.13.11.3

3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
type: BiochemicalReaction
id: R00017
left: 3-carboxy-cis,cis-muconate
right: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
catalysis: Catalysis
  controller: 3-carboxy-cis,cis-muconate cycloisomerase
  controlled: 3-carboxy-cis,cis-muconate → 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate

3-carboxy-cis,cis-muconate cycloisomerase
type: Protein
id: E00012
EC number: 5.5.1.2

2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone
type: BiochemicalReaction
id: R00018
left: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate
right: 3-oxoadipate enol lactone
catalysis: Catalysis
  controller: 4-carboxymuconolactone decarboxylase
  controlled: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate → 3-oxoadipate enol lactone

4-carboxymuconolactone decarboxylase
type: Protein
id: E00013
EC number: 4.1.1.44

3-oxoadipate enol lactone → beta-ketoadipate
type: BiochemicalReaction
id: R00019
left: 3-oxoadipate enol lactone
right: beta-ketoadipate
catalysis: Catalysis
  controller: 3-oxoadipate enol-lactonase
  controlled: 3-oxoadipate enol lactone → beta-ketoadipate

3-oxoadipate enol-lactonase
type: Protein
id: E00014
EC number: 3.1.1.24