Substrate	Reference(s)	Comment(s)
3-hydroxybenzoic acid	Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097	-
4-hydroxybenzaldehyde	Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195	-
4-hydroxybenzoic acid	Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097; Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195	-
agropyron repens grass lignin	Antai, S. P., & Crawford, D. L. (1981). Degradation of Softwood, Hardwood, and Grass Lignocelluloses by Two Streptomyces Strains. Applied and Environmental Microbiology, 42(2), 378–380. https://doi.org/10.1128/aem.42.2.378-380.1981	-
alkali lignin	Salvachúa, D., Karp, E. M., Nimlos, C. T., Vardon, D. R., & Beckham, G. T. (2015). Towards lignin consolidated bioprocessing: simultaneous lignin depolymerization and product generation by bacteria. Green Chemistry, 17(11), 4951–4967. https://doi.org/10.1039/c5gc01165e	(from corn stover; ~30% lignin conversion, including Klason lignin and monomers)
benzaldehyde	Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195	-
benzoic acid	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
catechol	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097; Antai, S. P., & Crawford, D. L. (1983). Degradation of phenol by Streptomyces setonii. Canadian Journal of Microbiology, 29(1), 142–143. https://doi.org/10.1139/m83-022; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
cinnamic acid	Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
cis,cis-muconic acid	Antai, S. P., & Crawford, D. L. (1983). Degradation of phenol by Streptomyces setonii. Canadian Journal of Microbiology, 29(1), 142–143. https://doi.org/10.1139/m83-022; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
ferulic acid	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Fleige, C., Hansen, G., Kroll, J., & Steinbüchel, A. (2013). Investigation of the Amycolatopsis sp. Strain ATCC 39116 Vanillin Dehydrogenase and Its Impact on the Biotechnical Production of Vanillin. Applied and Environmental Microbiology, 79(1), 81–90. https://doi.org/10.1128/aem.02358-12; Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195	-
gentisic acid	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097	-
guaiacol	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097; Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
maple lignin	Antai, S. P., & Crawford, D. L. (1981). Degradation of Softwood, Hardwood, and Grass Lignocelluloses by Two Streptomyces Strains. Applied and Environmental Microbiology, 42(2), 378–380. https://doi.org/10.1128/aem.42.2.378-380.1981	-
p-coumaric acid	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
phenol	Antai, S. P., & Crawford, D. L. (1983). Degradation of phenol by Streptomyces setonii. Canadian Journal of Microbiology, 29(1), 142–143. https://doi.org/10.1139/m83-022; Barton, N., Horbal, L., Starck, S., Kohlstedt, M., Luzhetskyy, A., & Wittmann, C. (2018). Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metabolic Engineering, 45, 200–210. https://doi.org/10.1016/j.ymben.2017.12.001	-
protocatechuic acid	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097	-
spruce lignin	Antai, S. P., & Crawford, D. L. (1981). Degradation of Softwood, Hardwood, and Grass Lignocelluloses by Two Streptomyces Strains. Applied and Environmental Microbiology, 42(2), 378–380. https://doi.org/10.1128/aem.42.2.378-380.1981	-
vanillic acid	Pometto III, A. L., Sutherland, J. B., & Crawford, D. L. (1981). Streptomyces setonii: catabolism of vanillic acid via guaiacol and catechol. Canadian Journal of Microbiology, 27(6), 636–638. https://doi.org/10.1139/m81-097; Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195	-
vanillin	Davis, J. R., Goodwin, L. A., Woyke, T., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, S., Han, J., Pitluck, S., Nolan, M., Mikhailova, N., Land, M. L., & Sello, J. K. (2012). Genome Sequence of Amycolatopsis sp. Strain ATCC 39116, a Plant Biomass-Degrading Actinomycete. Journal of Bacteriology, 194(9), 2396–2397. https://doi.org/10.1128/jb.00186-12; Sutherland, J. B., Crawford, D. L., & Pometto III, A. L. (1983). Metabolism of cinnamic, p-coumaric, and ferulic acids by Streptomyces setonii. Canadian Journal of Microbiology, 29(10), 1253–1257. https://doi.org/10.1139/m83-195	-
veratrole	Sutherland, J. B. (1986). Demethylation of Veratrole by Cytochrome P-450 in Streptomyces setonii. Applied and Environmental Microbiology, 52(1), 98–100. https://doi.org/10.1128/aem.52.1.98-100.1986	-